Andrea Wirsching1, Christian Eberhardt2, Moritz C Wurnig3, Andreas Boss4, Mickaël Lesurtel5. 1. Swiss Hepato-Pancreatico-Biliary and Transplantation Center, Department of Surgery, University Hospital Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland. Electronic address: Wirsching.Andrea@gmail.com. 2. Institute for Diagnosic and Interventional Radiology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland. Electronic address: Christian.Eberhardt@usz.ch. 3. Institute for Diagnosic and Interventional Radiology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland. Electronic address: Moritz.Wurnig@usz.ch. 4. Institute for Diagnosic and Interventional Radiology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland. Electronic address: Andreas.Boss@usz.ch. 5. Swiss Hepato-Pancreatico-Biliary and Transplantation Center, Department of Surgery, University Hospital Zurich, Rämistrasse 100, CH-8091, Zürich, Switzerland. Electronic address: mickael.lesurtel@chu-lyon.fr.
Abstract
RATIONALE AND OBJECTIVES: Posthepatectomy liver failure (PHLF) remains challenging to diagnose and difficult to treat. The extent of transient regeneration-associated steatosis (TRAS) differs between successful liver regeneration and PHLF. This study aims to quantify TRAS by magnetic resonance imaging (MRI) after hepatectomy in mice. MATERIALS AND METHODS: Mice (C57BL/6) underwent either extended hepatectomy (EH) or standard hepatectomy (SH). Serial MRI on postoperative days 1-7 was used to compare TRAS and liver remnant growth between groups. Survival was also assessed. RESULTS: EH was associated with decreased survival and impaired proliferation when compared to SH (p = 0.02 and p = 0.03). MRI showed increased TRAS 48 h after EH compared to SH (11.8 ± 6% vs. 4.3 ± 2%, p < 0.001). Compared to EH survivors, death after EH was associated with increased TRAS 48 h postoperatively (16.4 ± 6% vs. 9.2 ± 5%, p = 0.02). CONCLUSIONS: EH is associated with increased TRAS and inferior outcomes when compared to SH. MRI may help to predict PHLF after hepatectomy.
RATIONALE AND OBJECTIVES: Posthepatectomy liver failure (PHLF) remains challenging to diagnose and difficult to treat. The extent of transient regeneration-associated steatosis (TRAS) differs between successful liver regeneration and PHLF. This study aims to quantify TRAS by magnetic resonance imaging (MRI) after hepatectomy in mice. MATERIALS AND METHODS:Mice (C57BL/6) underwent either extended hepatectomy (EH) or standard hepatectomy (SH). Serial MRI on postoperative days 1-7 was used to compare TRAS and liver remnant growth between groups. Survival was also assessed. RESULTS: EH was associated with decreased survival and impaired proliferation when compared to SH (p = 0.02 and p = 0.03). MRI showed increased TRAS 48 h after EH compared to SH (11.8 ± 6% vs. 4.3 ± 2%, p < 0.001). Compared to EH survivors, death after EH was associated with increased TRAS 48 h postoperatively (16.4 ± 6% vs. 9.2 ± 5%, p = 0.02). CONCLUSIONS: EH is associated with increased TRAS and inferior outcomes when compared to SH. MRI may help to predict PHLF after hepatectomy.