Kyle Steenland1, Vaughn Barry1, David Savitz2. 1. From the Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA. 2. Department of Epidemiology, School of Public Health, Brown University, Providence, RI.
Abstract
BACKGROUND: A recent meta-analysis of 15 studies found a change in birthweight of -12.8 g (95% CI = -23.1, -2.38) per ng/ml PFOA in maternal or cord blood and -27.1 g (-50.6, -3.6) per log ng/ml PFOA. Almost all studies were done in low-exposed populations. There are nine new studies, adding 6,019 births to the previous 6,937 births. METHODS: We conducted a meta-analysis of 24 studies. To combine all results, we approximated results for untransformed PFOA from nine studies using log-transformed PFOA. We also included another large study, excluded from previous analyses, in a sensitivity analysis. RESULTS: We found a change of birthweight of -10.5 g (-16.7, -4.4) for every ng/ml PFOA in maternal or cord blood. After adding one previously excluded large study, we found little evidence of an association (-1.0 g; 95% CI = -2.4, 0.4). Restricting to studies where blood was sampled from mothers early in the pregnancy or shortly before conception (5,393 births), we found little association of PFOA with birthweight (-3.3 g [-9.6, 3.0]). In studies where blood was sampled late in the pregnancy (7563 pregnancies), lower birthweight was associated with higher PFOA (-17.8 [-25.0, -10.6]). CONCLUSION: Present human evidence provides only modest support for decreased birthweight with increasing PFOA. Studies with a wide range of exposure, and studies with blood sampled early in pregnancy, showed little or no association of PFOA with birthweight. These are studies in which confounding and reverse causality would be of less concern.
BACKGROUND: A recent meta-analysis of 15 studies found a change in birthweight of -12.8 g (95% CI = -23.1, -2.38) per ng/ml PFOA in maternal or cord blood and -27.1 g (-50.6, -3.6) per log ng/ml PFOA. Almost all studies were done in low-exposed populations. There are nine new studies, adding 6,019 births to the previous 6,937 births. METHODS: We conducted a meta-analysis of 24 studies. To combine all results, we approximated results for untransformed PFOA from nine studies using log-transformed PFOA. We also included another large study, excluded from previous analyses, in a sensitivity analysis. RESULTS: We found a change of birthweight of -10.5 g (-16.7, -4.4) for every ng/ml PFOA in maternal or cord blood. After adding one previously excluded large study, we found little evidence of an association (-1.0 g; 95% CI = -2.4, 0.4). Restricting to studies where blood was sampled from mothers early in the pregnancy or shortly before conception (5,393 births), we found little association of PFOA with birthweight (-3.3 g [-9.6, 3.0]). In studies where blood was sampled late in the pregnancy (7563 pregnancies), lower birthweight was associated with higher PFOA (-17.8 [-25.0, -10.6]). CONCLUSION: Present human evidence provides only modest support for decreased birthweight with increasing PFOA. Studies with a wide range of exposure, and studies with blood sampled early in pregnancy, showed little or no association of PFOA with birthweight. These are studies in which confounding and reverse causality would be of less concern.
Authors: Anne P Starling; John L Adgate; Richard F Hamman; Katerina Kechris; Antonia M Calafat; Dana Dabelea Journal: Environ Int Date: 2019-07-05 Impact factor: 9.621
Authors: Rebecca M Lebeaux; Brett T Doherty; Lisa G Gallagher; R Thomas Zoeller; Andrew N Hoofnagle; Antonia M Calafat; Margaret R Karagas; Kimberly Yolton; Aimin Chen; Bruce P Lanphear; Joseph M Braun; Megan E Romano Journal: Environ Res Date: 2020-03-16 Impact factor: 6.498
Authors: Lydiane Agier; Xavier Basagaña; Carles Hernandez-Ferrer; Léa Maitre; Ibon Tamayo Uria; Jose Urquiza; Sandra Andrusaityte; Maribel Casas; Montserrat de Castro; Enrique Cequier; Leda Chatzi; David Donaire-Gonzalez; Lise Giorgis-Allemand; Juan R Gonzalez; Regina Grazuleviciene; Kristine B Gützkow; Line S Haug; Amrit K Sakhi; Rosemary R C McEachan; Helle M Meltzer; Mark Nieuwenhuijsen; Oliver Robinson; Theano Roumeliotaki; Jordi Sunyer; Cathrine Thomsen; Marina Vafeiadi; Antonia Valentin; Jane West; John Wright; Valérie Siroux; Martine Vrijheid; Rémy Slama Journal: Int J Epidemiol Date: 2020-04-01 Impact factor: 7.196
Authors: Kristin J Marks; Penelope P Howards; Melissa M Smarr; W Dana Flanders; Kate Northstone; Johnni H Daniel; Andreas Sjödin; Antonia M Calafat; Terryl J Hartman Journal: Epidemiology Date: 2021-07-01 Impact factor: 4.860
Authors: Stephanie M Eick; Elizabeth A Enright; Amy M Padula; Max Aung; Sarah D Geiger; Lara Cushing; Jessica Trowbridge; Alexander P Keil; Hyoung Gee Baek; Sabrina Smith; June-Soo Park; Erin DeMicco; Susan L Schantz; Tracey J Woodruff; Rachel Morello-Frosch Journal: Environ Int Date: 2022-04-09 Impact factor: 13.352
Authors: Christos Symeonides; Manuel Brunner; Yannick Mulders; Priyanka Toshniwal; Matthew Cantrell; Louise Mofflin; Sarah Dunlop Journal: J Paediatr Child Health Date: 2021-11 Impact factor: 1.929