Literature DB >> 3006340

Analysis of the autophosphorylation activity of transformation defective mutants of avian erythroblastosis virus.

M J Hayman, G Kitchener, J Knight, J McMahon, R Watson, H Beug.   

Abstract

The v-erb B protein of avian erythroblastosis virus (AEV) possesses an associated protein kinase activity in vitro. Analysis of temperature-sensitive mutants, and nonconditional host range mutants of AEV demonstrated that there was no simple correlation between this autophosphorylation activity and the transformation ability of the various AEV mutants. These data suggest that although this kinase activity may be central to transformation by AEV it is in itself insufficient.

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Year:  1986        PMID： 3006340     DOI： 10.1016/0042-6822(86)90287-4

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  5 in total

1.  Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression.

Authors:  R C Wek; M Ramirez; B M Jackson; A G Hinnebusch
Journal:  Mol Cell Biol       Date:  1990-06       Impact factor: 4.272

2.  Protein tyrosine kinase activities of the epidermal growth factor receptor and ErbB proteins: correlation of oncogenic activation with altered kinetics.

Authors:  N Nair; R J Davis; H L Robinson
Journal:  Mol Cell Biol       Date:  1992-05       Impact factor: 4.272

3.  Analysis of the role of the Shc and Grb2 proteins in signal transduction by the v-ErbB protein.

Authors:  S Meyer; K LaBudda; J McGlade; M J Hayman
Journal:  Mol Cell Biol       Date:  1994-05       Impact factor: 4.272

4.  Ron tyrosine kinase receptor synergises with EGFR to confer adverse features in head and neck squamous cell carcinoma.

Authors:  J Keller; A S Nimnual; K R Shroyer; C Joy; I Ischenko; C S Chandler; L M Dong; M J Hayman; E L Chan
Journal:  Br J Cancer       Date:  2013-06-25       Impact factor: 7.640

5.  Truncation of the human EGF receptor leads to differential transforming potentials in primary avian fibroblasts and erythroblasts.

Authors:  K Khazaie; T J Dull; T Graf; J Schlessinger; A Ullrich; H Beug; B Vennström
Journal:  EMBO J       Date:  1988-10       Impact factor: 11.598
  5 in total

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