Literature DB >> 3006336

Genetic analysis of the 3' early region transformation and replication functions of bovine papillomavirus type 1.

D E Groff, W D Lancaster.   

Abstract

Cell transformation by BPV-1 is dependent on sequences confined to a region comprising only 69% of the viral DNA. Analysis of this subgenomic fragment of the viral genome has revealed a composite of functions. To further study this region of the BPV-1 genome, we constructed mutants affecting the 3' half of the transforming region. These mutations have revealed a plasmid maintenance function for the E2 ORF and a requirement that the 3' half of E5 be intact for in vitro mouse cell transformation. Cotransfection experiments revealed that phenotypic complementation (wild type transformation efficiency and autonomous replication of viral DNA) resulted in recombination between input plasmids in the majority of cases. However, rare cases were encountered where the wild type phenotype was observed with no evidence of recombination between input plasmids. These data suggest trans-acting functions of the E2 and E5 ORFs in viral DNA replication and the E5 ORF in cell transformation.

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Year:  1986        PMID： 3006336     DOI： 10.1016/0042-6822(86)90281-3

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  50 in total

1.  A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase.

Authors:  D J Goldstein; R Kulke; D Dimaio; R Schlegel
Journal:  J Virol       Date:  1992-01       Impact factor: 5.103

2.  Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region.

Authors:  J Moreno-Lopez; H Ahola; A Eriksson; P Bergman; U Pettersson
Journal:  J Virol       Date:  1987-11       Impact factor: 5.103

3.  Mutational analysis of the 3' open reading frames and the splice junction at nucleotide 3225 of bovine papillomavirus type 1.

Authors:  P L Hermonat; P M Howley
Journal:  J Virol       Date:  1987-12       Impact factor: 5.103

4.  Cloning and characterization of a papillomavirus associated with papillomas and carcinomas in the European harvest mouse (Micromys minutus).

Authors:  M K O'Banion; M E Reichmann; J P Sundberg
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

Review 5.  Papillomavirus DNA replication.

Authors:  P F Lambert
Journal:  J Virol       Date:  1991-07       Impact factor: 5.103

6.  Formation of the complex of bovine papillomavirus E1 and E2 proteins is modulated by E2 phosphorylation and depends upon sequences within the carboxyl terminus of E1.

Authors:  M Lusky; E Fontane
Journal:  Proc Natl Acad Sci U S A       Date:  1991-07-15       Impact factor: 11.205

7.  The genomes of the animal papillomaviruses European elk papillomavirus, deer papillomavirus, and reindeer papillomavirus contain a novel transforming gene (E9) near the early polyadenylation site.

Authors:  A Eriksson; A C Stewart; J Moreno-Lopéz; U Pettersson
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

Review 8.  The bovine papillomavirus E5 protein and the PDGF beta receptor: it takes two to tango.

Authors:  Kristina Talbert-Slagle; Daniel DiMaio
Journal:  Virology       Date:  2008-11-06       Impact factor: 3.616

9.  Characterization of the cis elements involved in basal and E2-transactivated expression of the bovine papillomavirus P2443 promoter.

Authors:  B A Spalholz; S B Vande Pol; P M Howley
Journal:  J Virol       Date:  1991-02       Impact factor: 5.103

10.  E5 oncoprotein transmembrane mutants dissociate fibroblast transforming activity from 16-kilodalton protein binding and platelet-derived growth factor receptor binding and phosphorylation.

Authors:  J Sparkowski; M Mense; J Anders; R Schlegel
Journal:  J Virol       Date:  1996-04       Impact factor: 5.103
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