Literature DB >> 3006250

Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density.

O E Brodde, R Kretsch, K Ikezono, H R Zerkowski, J C Reidemeister.   

Abstract

In human right atria obtained from 21 patients during open-heart surgery, beta-adrenoceptor density [assessed by iodine-125-labeled (-)-cyanopindolol binding] and responsiveness (positive inotropic responses to isoprenaline) were linearly related to the beta-adrenoceptor density in the corresponding circulating lymphocytes. This direct relation of human myocardial and lymphocyte beta-adrenoceptor alterations, therefore, makes it possible to monitor drug- or disease-induced beta-adrenoceptor changes in tissues not easily accessible in humans.

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Year:  1986        PMID： 3006250     DOI： 10.1126/science.3006250

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  31 in total

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7.  Association of in vivo β-adrenergic receptor sensitivity with inflammatory markers in healthy subjects.

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8.  Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.

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Journal:  Clin Transl Sci       Date:  2010-02       Impact factor: 4.689

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10.  Beta-receptor responsiveness after desipramine treatment.

Authors:  R Pohl; G N Pandey; V K Yeragani; R Balon; J M Davis; R Berchou
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530
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