[Amphetamine analog of ruthenocene as a radiodiagnostic agent: brain affinity of ruthenocenoyl-isopropylamine].

N-alkyl derivatives of 1-ruthenocenoyl-2-aminopropane (Rc-amphetamine) were labelled with 103Ru and their organ distributions were measured in mice and rats. All Rc-amphetamines showed a high affinity for brain and lung. A concentration ratio brain/blood up to 17:1 and lung/blood up to 80:1 was measured. The advantages of 97Ru labelled Rc-amphetamine compared to 123I labelled amphetamine for measurement of regional cerebral blood flow are discussed.