Literature DB >> 30061423

Zooming in on a small multidrug transporter reveals details of asymmetric protonation.

Jana Shen1.   

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Year:  2018        PMID： 30061423      PMCID： PMC6094094          DOI： 10.1073/pnas.1810814115

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  22 in total

1.  Protonation-dependent conformational dynamics of the multidrug transporter EmrE.

Authors:  Reza Dastvan; Axel W Fischer; Smriti Mishra; Jens Meiler; Hassane S Mchaourab
Journal:  Proc Natl Acad Sci U S A       Date:  2016-01-19       Impact factor: 11.205

Review 2.  Small multidrug resistance proteins: a multidrug transporter family that continues to grow.

Authors:  Denice C Bay; Kenton L Rommens; Raymond J Turner
Journal:  Biochim Biophys Acta       Date:  2007-08-24

3.  Identification of tyrosine residues critical for the function of an ion-coupled multidrug transporter.

Authors:  Dvir Rotem; Sonia Steiner-Mordoch; Shimon Schuldiner
Journal:  J Biol Chem       Date:  2006-05-03       Impact factor: 5.157

4.  Constant pH Molecular Dynamics Reveals How Proton Release Drives the Conformational Transition of a Transmembrane Efflux Pump.

Authors:  Zhi Yue; Wei Chen; Helen I Zgurskaya; Jana Shen
Journal:  J Chem Theory Comput       Date:  2017-11-20       Impact factor: 6.006

5.  The key residue for substrate transport (Glu14) in the EmrE dimer is asymmetric.

Authors:  Ines Lehner; Daniel Basting; Bjoern Meyer; Winfried Haase; Theofanis Manolikas; Christoph Kaiser; Michael Karas; Clemens Glaubitz
Journal:  J Biol Chem       Date:  2007-11-27       Impact factor: 5.157

Review 6.  Multiple molecular mechanisms for multidrug resistance transporters.

Authors:  Christopher F Higgins
Journal:  Nature       Date:  2007-04-12       Impact factor: 49.962

7.  Antiparallel EmrE exports drugs by exchanging between asymmetric structures.

Authors:  Emma A Morrison; Gregory T DeKoster; Supratik Dutta; Reza Vafabakhsh; Michael W Clarkson; Arjun Bahl; Dorothee Kern; Taekjip Ha; Katherine A Henzler-Wildman
Journal:  Nature       Date:  2011-12-18       Impact factor: 49.962

8.  Intrinsic conformational plasticity of native EmrE provides a pathway for multidrug resistance.

Authors:  Min-Kyu Cho; Anindita Gayen; James R Banigan; Maureen Leninger; Nathaniel J Traaseth
Journal:  J Am Chem Soc       Date:  2014-05-23       Impact factor: 15.419

9.  Protonation of a glutamate residue modulates the dynamics of the drug transporter EmrE.

Authors:  Anindita Gayen; Maureen Leninger; Nathaniel J Traaseth
Journal:  Nat Chem Biol       Date:  2016-01-11       Impact factor: 15.040

10.  Electrostatic lock in the transport cycle of the multidrug resistance transporter EmrE.

Authors:  Josh V Vermaas; Susan B Rempe; Emad Tajkhorshid
Journal:  Proc Natl Acad Sci U S A       Date:  2018-07-19       Impact factor: 11.205
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  2 in total

1.  Alternative proton-binding site and long-distance coupling in Escherichia coli sodium-proton antiporter NhaA.

Authors:  Jack A Henderson; Yandong Huang; Oliver Beckstein; Jana Shen
Journal:  Proc Natl Acad Sci U S A       Date:  2020-09-24       Impact factor: 11.205

2.  Assembly and regulation of the chlorhexidine-specific efflux pump AceI.

Authors:  Jani Reddy Bolla; Anna C Howes; Francesco Fiorentino; Carol V Robinson
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-07       Impact factor: 11.205
  2 in total

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