Valentina Ciaravino1, Nicolò Cardobi2, Riccardo DE Robertis2, Paola Capelli3, Davide Melisi4, Francesca Simionato4, Giovanni Marchegiani5, Roberto Salvia5, Mirko D'Onofrio6. 1. Department of Radiology, G.B. Rossi Hospital - University of Verona, Verona, Italy. 2. Department of Radiology, Casa di Cura Dott. Pederzoli, Peschiera del Garda, Verona, Italy. 3. Department of Pathology, G.B. Rossi Hospital - University of Verona, Verona, Italy. 4. Department of Oncology, G.B. Rossi Hospital - University of Verona, Verona, Italy. 5. Department of Surgery, G.B. Rossi Hospital - University of Verona, Verona, Italy. 6. Department of Radiology, G.B. Rossi Hospital - University of Verona, Verona, Italy mirko.donofrio@univr.it.
Abstract
BACKGROUND/AIM: Re-staging of ductal adenocarcinoma using computed tomography (CT) scan can be problematic so new imaging techniques and evaluation parameters are required. The aim of the study was to evaluate the added value of CT texture analysis in estimation of tissue changes in ductal adenocarcinoma downsized and resected after chemotherapy. MATERIALS AND METHODS: Patients with ductal adenocarcinoma downstaged after neoadjuvant treatment, and resected, were included. A pre- and post-treatment CT was obtained. In comparison, patients with disease progression were included for texture analysis evaluation at CT pre- and post-treatment. CT texture analysis results were compared. RESULTS: A total of 17 patients affected by un-resectable or borderline ductal adenocarcinoma reached the resectable stage after treatment. The comparison between Kurtosis pre- and Kurtosis post-treatment showed a statistically significant difference. On the contrary, in the comparison group composed of 14 patients with disease progression there was no statistical difference regarding this parameter. CONCLUSION: This evaluation may represent an added value in tumor tissue changes judgment and can be extremely useful to diagnose downstaging in those cases with no evident downsizing after chemotherapy. Copyright
BACKGROUND/AIM: Re-staging of ductal adenocarcinoma using computed tomography (CT) scan can be problematic so new imaging techniques and evaluation parameters are required. The aim of the study was to evaluate the added value of CT texture analysis in estimation of tissue changes in ductal adenocarcinoma downsized and resected after chemotherapy. MATERIALS AND METHODS:Patients with ductal adenocarcinoma downstaged after neoadjuvant treatment, and resected, were included. A pre- and post-treatment CT was obtained. In comparison, patients with disease progression were included for texture analysis evaluation at CT pre- and post-treatment. CT texture analysis results were compared. RESULTS: A total of 17 patients affected by un-resectable or borderline ductal adenocarcinoma reached the resectable stage after treatment. The comparison between Kurtosis pre- and Kurtosis post-treatment showed a statistically significant difference. On the contrary, in the comparison group composed of 14 patients with disease progression there was no statistical difference regarding this parameter. CONCLUSION: This evaluation may represent an added value in tumor tissue changes judgment and can be extremely useful to diagnose downstaging in those cases with no evident downsizing after chemotherapy. Copyright