Patrizia Ferroni1,2, Mario Roselli3, Oreste C Buonomo4, Antonella Spila2, Ilaria Portarena3, Anastasia Laudisi3, Maria G Valente2, Silvana P Pirillo5, Lucio Fortunato6, Leopoldo Costarelli7, Francesco Cavaliere6,8, Fiorella Guadagni9,2. 1. Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy patrizia.ferroni@sanraffaele.it. 2. Interinstitutional Multidisciplinary Biobank (BioBIM), IRCCS San Raffaele Pisana, Rome, Italy. 3. Department of Systems Medicine, Medical Oncology, Policlinico Tor Vergata Biospecimen Cancer Repository (PTV Bio.Ca.Re.), Tor Vergata University of Rome, Rome, Italy. 4. Department of Surgery, Tor Vergata University of Rome, Rome, Italy. 5. Department of Radiology, San Giovanni Hospital-Addolorata, Rome, Italy. 6. Breast Unit, San Giovanni Hospital-Addolorata, Rome, Italy. 7. Department of Pathology, San Giovanni Hospital-Addolorata, Rome, Italy. 8. Breast Unit, Belcolle Hospital, Viterbo, Italy. 9. Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, Rome, Italy.
Abstract
BACKGROUND/AIM: To investigate whether neutrophil-to-lymphocyte ratio (NLR) might represent an additional biological criterion able to identify patients with worse prognosis within the 8th edition TNM prognostic staging system for breast cancer (BC). PATIENTS AND METHODS: Pre-treatment NLR was retrospectively analyzed in 475 BC women prospectively followed for a mean time of 3.8 years. The optimal NLR cutoff, identified by ROC analysis, was set at 2. RESULTS: Elevated pre-treatment NLR was associated with worse disease-free survival (DFS) (HR=2.28) and overall survival (OS) (HR=3.39). The prognostic value of NLR was mostly evident in stage I BC (HR for DFS=2.89; HR for OS=1.30), in whom NLR significantly stratified patients who developed distant metastasis (HR= 4.62), but not local recurrence. CONCLUSION: NLR might provide important information in risk stratification, especially in stage I BC patients in whom the presence of a high NLR might raise the question as to whether they should be more aggressively managed. Copyright
BACKGROUND/AIM: To investigate whether neutrophil-to-lymphocyte ratio (NLR) might represent an additional biological criterion able to identify patients with worse prognosis within the 8th edition TNM prognostic staging system for breast cancer (BC). PATIENTS AND METHODS: Pre-treatment NLR was retrospectively analyzed in 475 BC women prospectively followed for a mean time of 3.8 years. The optimal NLR cutoff, identified by ROC analysis, was set at 2. RESULTS: Elevated pre-treatment NLR was associated with worse disease-free survival (DFS) (HR=2.28) and overall survival (OS) (HR=3.39). The prognostic value of NLR was mostly evident in stage I BC (HR for DFS=2.89; HR for OS=1.30), in whom NLR significantly stratified patients who developed distant metastasis (HR= 4.62), but not local recurrence. CONCLUSION: NLR might provide important information in risk stratification, especially in stage I BC patients in whom the presence of a high NLR might raise the question as to whether they should be more aggressively managed. Copyright
Authors: Daniella Karassawa Zanoni; Cristina Valero; Marlena R McGill; Pablo H Montero; Jatin P Shah; Richard J Wong; Ian Ganly; Snehal G Patel Journal: Oral Oncol Date: 2021-12-01 Impact factor: 5.972
Authors: Jeong Won Lee; Sung Yong Kim; Sun Wook Han; Jong Eun Lee; Hyun Ju Lee; Nam Hun Heo; Sang Mi Lee Journal: EJNMMI Res Date: 2020-06-30 Impact factor: 3.138