Mubarek Abera1, Markos Tesfaye2, Charlotte Hanlon3, Bitiya Admassu4, Tsinuel Girma5, Jonathan C Wells6, Pernille Kæstel7, Christian Ritz7, Rasmus Wibaek8, Kim F Michaelsen7, Henrik Friis7, Gregers S Andersen9. 1. Department of Psychiatry, Faculty of Medical Sciences, Jimma University, Jimma, Ethiopia; Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. Electronic address: mubarek.abera@ju.edu.et. 2. Department of Psychiatry, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. 3. Department of Psychiatry, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; Center for Global Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. 4. Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark; Department of Population and Family Health, Faculty of Public Health, Jimma University, Jimma, Ethiopia. 5. Department of Pediatrics and Child Health, Faculty of Medical Sciences, Jimma University, Jimma, Ethiopia. 6. Childhood Nutrition Research Center UCL Institute of Child Health, London, United Kingdom. 7. Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark. 8. Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark; Steno Diabetes Center Copenhagen, Gentofte, Denmark. 9. Steno Diabetes Center Copenhagen, Gentofte, Denmark.
Abstract
OBJECTIVE: To examine the relationship between body composition-specifically fat mass (FM) and fat-free mass (FFM)-in early infancy, and mental health outcomes in early childhood. STUDY DESIGN: In the Infant Anthropometry and Body Composition birth cohort study from Ethiopia, body composition was measured at birth and 1.5, 2.5, 3.5, 4.5, and 6 months of age. Mental health was assessed at 5 years of age using the approved Amharic version of the Strengths and Difficulties Questionnaire (SDQ), a parent report scale covering 4 different domains providing a total difficulties score. The associations of FM or FFM at birth as well as during early infancy, with SDQ score at 5 years of age were examined using multiple linear regression analyses. RESULTS: At 5 years of age, the mean ± SD for SDQ score was 10.4 ± 5.8. FM at birth was positively and FFM negatively associated with SDQ score. For each kg increase in FM at birth, the SDQ score at 5 years was 5.7 points higher (β = 5.7; 95% CI, 1.4-10.0). In contrast, for each kilogram increase in FFM at birth, the SDQ score was 3.9 points lower (β = -3.9; 95% CI, -7.0 to -0.8). Neither FM nor FFM accretion rate during early infancy were associated with SDQ score at 5 years of age. CONCLUSIONS: Fetal rather than infant body composition was associated with SDQ score at 5 years of age. Greater FFM accretion during fetal life may have contributed to more optimal neurobehavioral development during early life. However, the potential mechanisms underlying the observed associations need further investigation.
OBJECTIVE: To examine the relationship between body composition-specifically fat mass (FM) and fat-free mass (FFM)-in early infancy, and mental health outcomes in early childhood. STUDY DESIGN: In the Infant Anthropometry and Body Composition birth cohort study from Ethiopia, body composition was measured at birth and 1.5, 2.5, 3.5, 4.5, and 6 months of age. Mental health was assessed at 5 years of age using the approved Amharic version of the Strengths and Difficulties Questionnaire (SDQ), a parent report scale covering 4 different domains providing a total difficulties score. The associations of FM or FFM at birth as well as during early infancy, with SDQ score at 5 years of age were examined using multiple linear regression analyses. RESULTS: At 5 years of age, the mean ± SD for SDQ score was 10.4 ± 5.8. FM at birth was positively and FFM negatively associated with SDQ score. For each kg increase in FM at birth, the SDQ score at 5 years was 5.7 points higher (β = 5.7; 95% CI, 1.4-10.0). In contrast, for each kilogram increase in FFM at birth, the SDQ score was 3.9 points lower (β = -3.9; 95% CI, -7.0 to -0.8). Neither FM nor FFM accretion rate during early infancy were associated with SDQ score at 5 years of age. CONCLUSIONS: Fetal rather than infant body composition was associated with SDQ score at 5 years of age. Greater FFM accretion during fetal life may have contributed to more optimal neurobehavioral development during early life. However, the potential mechanisms underlying the observed associations need further investigation.
Authors: Adriana Vázquez-Vázquez; Mary S Fewtrell; Hidekel Chan-García; Carolina Batún-Marrufo; Federico Dickinson; Jonathan C Wells Journal: Philos Trans R Soc Lond B Biol Sci Date: 2021-05-03 Impact factor: 6.671
Authors: Bitiya Admassu; Jonathan C K Wells; Tsinuel Girma; Tefera Belachew; Christian Ritz; Victor Owino; Mubarek Abera; Rasmus Wibaek; Kim F Michaelsen; Pernille Kæstel; Henrik Friis; Gregers S Andersen Journal: Nutr Diabetes Date: 2018-09-07 Impact factor: 5.097
Authors: Fanny Petermann-Rocha; Nirmala Rao; Jill P Pell; Carlos Celis-Morales; Ian C K Wong; Frederick K Ho; Patrick Ip Journal: JAMA Netw Open Date: 2022-01-04
Authors: Mette F Olsen; Ann-Sophie Iuel-Brockdorff; Charles W Yaméogo; Bernardette Cichon; Christian Fabiansen; Suzanne Filteau; Kevin Phelan; Albertine Ouédraogo; Jonathan C Wells; André Briend; Kim F Michaelsen; Lotte Lauritzen; Christian Ritz; Per Ashorn; Vibeke B Christensen; Melissa Gladstone; Henrik Friis Journal: Matern Child Nutr Date: 2019-12-11 Impact factor: 3.092