Literature DB >> 30060810

The Role of Ceramide 1-Phosphate in Tumor Cell Survival and Dissemination.

Antonio Gomez-Muñoz1.   

Abstract

Ceramide 1-phosphate (C1P) is a pleiotropic bioactive sphingolipid metabolite capable of regulating key physiologic cell functions and promoting pathologic processes. Concerning pathology, C1P or ceramide kinase (CerK), the enzyme responsible for its biosynthesis in mammalian cells, has been implicated in cancer cell growth, survival, and dissemination and is involved in inflammatory responses associated with different types of cancer cells. The mechanisms or signaling pathways mediating these C1P actions have only been partially described. This chapter reviews recent progress in identifying signal transduction pathways involved in the promotion of cancer cell growth, survival, and dissemination by CerK and C1P.
Copyright © 2018 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Apoptosis; Cell migration; Ceramide 1-phosphate; Ceramides; Leukemia; Lung cancer; Metastasis; Neuroblastoma; Pancreas cancer; Sphingolipids

Mesh：

Substances：

Year:  2018        PMID： 30060810     DOI： 10.1016/bs.acr.2018.04.012

Source DB:  PubMed          Journal:  Adv Cancer Res        ISSN： 0065-230X            Impact factor:   6.242


  9 in total

1.  Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells.

Authors:  Li-Pin Kao; Samy A F Morad; Traci S Davis; Matthew R MacDougall; Miki Kassai; Noha Abdelmageed; Todd E Fox; Mark Kester; Thomas P Loughran; Jose' L Abad; Gemma Fabrias; Su-Fern Tan; David J Feith; David F Claxton; Sarah Spiegel; Kelsey H Fisher-Wellman; Myles C Cabot
Journal:  J Lipid Res       Date:  2019-07-30       Impact factor: 5.922

2.  Regulation of the amount of ceramide-1-phosphate synthesized in differentiated human podocytes.

Authors:  Shamroop Kumar Mallela; Alla Mitrofanova; Sandra Merscher; Alessia Fornoni
Journal:  Biochim Biophys Acta Mol Cell Biol Lipids       Date:  2019-09-02       Impact factor: 4.698

3.  Ceramide kinase mediates intrinsic resistance and inferior response to chemotherapy in triple-negative breast cancer by upregulating Ras/ERK and PI3K/Akt pathways.

Authors:  Shan Zhu; Yulin Xu; Lijun Wang; Shichong Liao; Yuan Wang; Manman Shi; Yi Tu; Yurong Zhou; Wen Wei
Journal:  Cancer Cell Int       Date:  2021-01-11       Impact factor: 5.722

4.  Ceramide kinase regulates TNF-α-induced immune responses in human monocytic cells.

Authors:  Fatema Al-Rashed; Zunair Ahmad; Ashley J Snider; Reeby Thomas; Shihab Kochumon; Motasem Melhem; Sardar Sindhu; Lina M Obeid; Fahd Al-Mulla; Yusuf A Hannun; Rasheed Ahmad
Journal:  Sci Rep       Date:  2021-04-15       Impact factor: 4.379

Review 5.  Implication of Ceramide Kinase/C1P in Cancer Development and Progression.

Authors:  Laura Camacho; Alberto Ouro; Ana Gomez-Larrauri; Arkaitz Carracedo; Antonio Gomez-Muñoz
Journal:  Cancers (Basel)       Date:  2022-01-04       Impact factor: 6.639

Review 6.  Molecular Mechanisms, Biomarkers and Emerging Therapies for Chemotherapy Resistant TNBC.

Authors:  Paola Ferrari; Cristian Scatena; Matteo Ghilli; Irene Bargagna; Giulia Lorenzini; Andrea Nicolini
Journal:  Int J Mol Sci       Date:  2022-01-31       Impact factor: 5.923

Review 7.  Emerging Roles of Ceramides in Breast Cancer Biology and Therapy.

Authors:  Purab Pal; G Ekin Atilla-Gokcumen; Jonna Frasor
Journal:  Int J Mol Sci       Date:  2022-09-23       Impact factor: 6.208

Review 8.  Emerging roles for human glycolipid transfer protein superfamily members in the regulation of autophagy, inflammation, and cell death.

Authors:  Shrawan K Mishra; Yong-Guang Gao; Xianqiong Zou; Daniel J Stephenson; Lucy Malinina; Edward H Hinchcliffe; Charles E Chalfant; Rhoderick E Brown
Journal:  Prog Lipid Res       Date:  2020-04-24       Impact factor: 14.673

Review 9.  S1P/S1P Receptor Signaling in Neuromuscolar Disorders.

Authors:  Elisabetta Meacci; Mercedes Garcia-Gil
Journal:  Int J Mol Sci       Date:  2019-12-17       Impact factor: 5.923
  9 in total

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