Najib Aziz1, Joshua J Quint1, Elizabeth C Breen2, John Oishi1, Beth D Jamieson3, Otoniel Martinez-Maza4, Roger Detels1,3. 1. Department of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California. 2. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, California. 3. Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. 4. Department of Obstetrics & Gynecology, Microbiology, Immunology, and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, California.
Abstract
BACKGROUND: Clinicians often use population-based reference intervals (RIs) when interpreting patient results. However, this method can present problems if the analyte in question has wide variability from person to person. METHODS: We examined the biological variation of routine hematologic markers in 82 white non-Hispanic men every 6 months during a 30-year period, to determine the usefulness of population-based RIs and age-related decline of hematological markers. RESULTS: Many of these markers showed significant person-to-person differences (index of individuality <1.4 in 10/11 markers) and change over time with a decrease in mean for white blood cells (WBCs), red blood cells (RBCs), hemoglobin, hematocrit, platelets, and neutrophils. The mean increased for monocytes, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) (all P <.05). CONCLUSION: Longitudinal analysis demonstrated significant decline in hematologic marker counts, with the exception of MCV and MCH. Establishment of a personalized baseline for hematologic assessments may be more useful to clinicians than previous methods.
BACKGROUND: Clinicians often use population-based reference intervals (RIs) when interpreting patient results. However, this method can present problems if the analyte in question has wide variability from person to person. METHODS: We examined the biological variation of routine hematologic markers in 82 white non-Hispanic men every 6 months during a 30-year period, to determine the usefulness of population-based RIs and age-related decline of hematological markers. RESULTS: Many of these markers showed significant person-to-person differences (index of individuality <1.4 in 10/11 markers) and change over time with a decrease in mean for white blood cells (WBCs), red blood cells (RBCs), hemoglobin, hematocrit, platelets, and neutrophils. The mean increased for monocytes, mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) (all P <.05). CONCLUSION: Longitudinal analysis demonstrated significant decline in hematologic marker counts, with the exception of MCV and MCH. Establishment of a personalized baseline for hematologic assessments may be more useful to clinicians than previous methods.
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