Jonathan P Piccini1, Sean D Pokorney2, Kevin J Anstrom2, Olaf Oldenburg3, Naresh M Punjabi4, Mona Fiuzat2, Gudaye Tasissa2, David J Whellan5, JoAnn Lindenfeld6, Adam Benjafield7, Holger Woehrle7, Amy Blase7, Christopher M O'Connor8. 1. Department of Medicine, Duke University and Duke Clinical Research Institute, Durham, North Carolina. Electronic address: jonathan.piccini@duke.edu. 2. Department of Medicine, Duke University and Duke Clinical Research Institute, Durham, North Carolina. 3. Department of Cardiology, Ruhr University Bochum, Bad Oeynhausen, Germany. 4. Department of Medicine, Johns Hopkins University, Baltimore, Maryland. 5. Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania. 6. Department of Medicine, Vanderbilt University, Nashville, Tennessee. 7. ResMed Science Center, ResMed, San Diego, California. 8. Department of Medicine, Duke University and Duke Clinical Research Institute, Durham, North Carolina; Inova Heart and Vascular Institute, Falls Church, Virginia.
Abstract
BACKGROUND:Patients with heart failure and sleep apnea are at increased risk for developing arrhythmias. Whether treatment of sleep apnea reduces arrhythmias is unknown. OBJECTIVE: The purpose of this study was to determine whether adaptive servo-ventilation (ASV) with optimal medical therapy (OMT) reduces atrial fibrillation (AF) and/orventricular tachycardia/ventricular fibrillation (VT/VF) burden compared to OMT alone. METHODS: We conducted a prospective substudy of patients with pacemakers/defibrillators in the Cardiovascular Improvements with Minute Ventilation-Targeted ASV Therapy in Heart Failure (CAT-HF) trial. Change in arrhythmia burden was compared using a mixed model analysis to account for multiple measurements per patient. RESULTS: Among 35 randomized patients eligible and analyzed (19 ASV, 16 OMT only) in the AF cohort, mean age was 64 ± 12 years, 23% were women (n = 8), 49% had previous AF (n = 17), 89% had reduced ejection fraction (n = 31), and mean apnea hypopnea index was 41 ± 17 events per hour. Baseline characteristics were similar between groups. Change in AF burden from baseline to follow-up was -15.8% ± 36.5% with ASV vs +23.7% ± 36.2% with OMT (P = .034). There was no significant change in the AF cohort in the mean number of VT/VF events: +3.3 ± 14.9 events with ASV vs -0.3 ± 7.3 events with OMT (P = .58). Five subjects had appropriate therapies for VT/VF in the ASV arm vs 6 subjects in the OMT arm. CONCLUSION: This study provides proof of concept that treatment of sleep apnea with ASV leads to reduction in AF burden compared with OMT alone, without an increase in VT/VF events. This hypothesis should be tested in a large outcomes trial. Crown
RCT Entities:
BACKGROUND:Patients with heart failure and sleep apnea are at increased risk for developing arrhythmias. Whether treatment of sleep apnea reduces arrhythmias is unknown. OBJECTIVE: The purpose of this study was to determine whether adaptive servo-ventilation (ASV) with optimal medical therapy (OMT) reduces atrial fibrillation (AF) and/or ventricular tachycardia/ventricular fibrillation (VT/VF) burden compared to OMT alone. METHODS: We conducted a prospective substudy of patients with pacemakers/defibrillators in the Cardiovascular Improvements with Minute Ventilation-Targeted ASV Therapy in Heart Failure (CAT-HF) trial. Change in arrhythmia burden was compared using a mixed model analysis to account for multiple measurements per patient. RESULTS: Among 35 randomized patients eligible and analyzed (19 ASV, 16 OMT only) in the AF cohort, mean age was 64 ± 12 years, 23% were women (n = 8), 49% had previous AF (n = 17), 89% had reduced ejection fraction (n = 31), and mean apnea hypopnea index was 41 ± 17 events per hour. Baseline characteristics were similar between groups. Change in AF burden from baseline to follow-up was -15.8% ± 36.5% with ASV vs +23.7% ± 36.2% with OMT (P = .034). There was no significant change in the AF cohort in the mean number of VT/VF events: +3.3 ± 14.9 events with ASV vs -0.3 ± 7.3 events with OMT (P = .58). Five subjects had appropriate therapies for VT/VF in the ASV arm vs 6 subjects in the OMT arm. CONCLUSION: This study provides proof of concept that treatment of sleep apnea with ASV leads to reduction in AF burden compared with OMT alone, without an increase in VT/VF events. This hypothesis should be tested in a large outcomes trial. Crown
Authors: Christoph Fisser; Lara Gall; Jannis Bureck; Victoria Vaas; Jörg Priefert; Sabine Fredersdorf; Florian Zeman; Dominik Linz; Holger Woehrle; Renaud Tamisier; Helmut Teschler; Martin R Cowie; Michael Arzt Journal: Front Cardiovasc Med Date: 2022-06-20