Literature DB >> 3005958

2-(4-phenylpiperidino) cyclohexanol (AH5183) decreases quantal size at the frog neuromuscular junction.

W Van der Kloot.   

Abstract

AH5183 was studied because it inhibits acetylcholine transport into synaptic vesicles. The drug apparently is a slow-acting anti-cholinesterase, so further experiments were performed with this enzyme inhibited. Soaking for hours in AH5183 in Ringer does not decrease quantal size. However, a few minutes of tetanic nerve stimulation results in a marked decrease in quantal size. Quantal size also decreased after hours in a hypertonic Ringer containing the drug.

Entities:  

Mesh：

Substances：

Year:  1986        PMID： 3005958     DOI： 10.1007/bf00582958

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  16 in total

1.  On the factors which determine the amplitude of the miniature end-plate potential.

Authors:  B KATZ; S THESLEFF
Journal:  J Physiol       Date:  1957-07-11       Impact factor: 5.182

2.  Changes in end-plate activity produced by presynaptic polarization.

Authors:  J DEL CASTILLO; B KATZ
Journal:  J Physiol       Date:  1954-06-28       Impact factor: 5.182

3.  The effects of tetraphenylboron on spontaneous transmitter release at the frog neuromuscular junction.

Authors:  I G Marshall; R L Parsons
Journal:  Br J Pharmacol       Date:  1975-07       Impact factor: 8.739

4.  Quantal size is not altered by abrupt changes in nerve terminal volume.

Authors:  W Van der Kloot
Journal:  Nature       Date:  1978-02-09       Impact factor: 49.962

5.  Variability of transmitter quanta released during incorporation of a false transmitter into cholinergic nerve terminals.

Authors:  W A Large; H P Rang
Journal:  J Physiol       Date:  1978-12       Impact factor: 5.182

6.  Factors affecting the rate of incorporation of a false transmitter into mammalian motor nerve terminals.

Authors:  W A Large; H P Rang
Journal:  J Physiol       Date:  1978-12       Impact factor: 5.182

7.  Activity increases quantal size at the frog neuromuscular junction.

Authors:  W Van der Kloot; T E Van der Kloot
Journal:  Experientia       Date:  1985-01-15

8.  Temperature effects on spontaneous and evoked quantal size at the frog neuromuscular junction.

Authors:  W Van der Kloot; I S Cohen
Journal:  J Neurosci       Date:  1984-09       Impact factor: 6.167

9.  Effects of membrane potential, temperature and neostigmine on the conductance change caused by a quantum or acetylcholine at the toad neuromuscular junction.

Authors:  P W Gage; R N McBurney
Journal:  J Physiol       Date:  1975-01       Impact factor: 5.182

10.  Inhibitory action of high formamide concentrations on excitation-contraction coupling in skeletal muscle.

Authors:  G E de Motta; F Córdoba; M de León; J del Castillo
Journal:  J Neurosci Res       Date:  1982       Impact factor: 4.164
View more
  13 in total

1.  Effects of reduced vesicular filling on synaptic transmission in rat hippocampal neurones.

Authors:  Q Zhou; C C Petersen; R A Nicoll
Journal:  J Physiol       Date:  2000-05-15       Impact factor: 5.182

2.  The vesicular acetylcholine transporter is required for neuromuscular development and function.

Authors:  Braulio M de Castro; Xavier De Jaeger; Cristina Martins-Silva; Ricardo D F Lima; Ernani Amaral; Cristiane Menezes; Patricia Lima; Cintia M L Neves; Rita G Pires; Thomas W Gould; Ian Welch; Christopher Kushmerick; Cristina Guatimosim; Ivan Izquierdo; Martin Cammarota; R Jane Rylett; Marcus V Gomez; Marc G Caron; Ronald W Oppenheim; Marco A M Prado; Vania F Prado
Journal:  Mol Cell Biol       Date:  2009-07-27       Impact factor: 4.272

3.  Acetylcholine recycling and release at rat motor nerve terminals studied using (-)-vesamicol and troxpyrrolium.

Authors:  T Searl; C Prior; I G Marshall
Journal:  J Physiol       Date:  1991-12       Impact factor: 5.182

4.  Bromoacetylcholine and acetylcholinesterase introduced via liposomes into motor nerve endings block increases in quantal size.

Authors:  E Brailoiu; W V der Kloot
Journal:  Pflugers Arch       Date:  1996-07       Impact factor: 3.657

5.  The packing of acetylcholine into quanta at the frog neuromuscular junction is inhibited by increases in intracellular sodium.

Authors:  W Van der Kloot
Journal:  Pflugers Arch       Date:  1988-08       Impact factor: 3.657

6.  A further study of the neuromuscular effects of vesamicol (AH5183) and of its enantiomer specificity.

Authors:  D Estrella; K L Green; C Prior; J Dempster; R F Halliwell; R S Jacobs; S M Parsons; R L Parsons; I G Marshall
Journal:  Br J Pharmacol       Date:  1988-04       Impact factor: 8.739

7.  Early induction by crotoxin of biphasic frequency changes and giant miniature endplate potentials in frog muscle.

Authors:  B J Hawgood; I C Smith; P N Strong
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

8.  The nature and origin of calcium-insensitive miniature end-plate potentials at rodent neuromuscular junctions.

Authors:  M T Lupa; N Tabti; S Thesleff; F Vyskocil; S P Yu
Journal:  J Physiol       Date:  1986-12       Impact factor: 5.182

9.  Increasing quantal size at the mouse neuromuscular junction and the role of choline.

Authors:  S P Yu; W Van der Kloot
Journal:  J Physiol       Date:  1991-02       Impact factor: 5.182

10.  The effects of vesamicol on trains of endplate currents and on focally recorded nerve terminal currents at mammalian neuromuscular junctions.

Authors:  K E Pemberton; C Prior; I G Marshall
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.