J Rymaszewska1, K M Urbanska2, D Szczesniak1, B Stanczykiewicz3, E Trypka1, A Zablocka4. 1. Wroclaw Medical University, Department of Psychiatry, L. Pasteur 10, 50-367 Wroclaw, Poland. 2. Wroclaw Medical University, Department of Psychiatry, L. Pasteur 10, 50-367 Wroclaw, Poland k.urbanska@hotmail.com. 3. Wroclaw Medical University, Department of Nervous System Diseases, Wroclaw, Poland. 4. Ludwik Hirszfeld Institute of Immunology and Experimental Therapy- Polish Academy of Sciences, Department of Immunochemistry, Wroclaw, Poland.
Abstract
BACKGROUND: Mild Cognitive Impairments (MCI) and dementia are still incurable. The Whole-Body Cryotherapy (WBC) - short, cyclic exposure to extremely low temperatures - has proven anti-inflammatory and anti-oxidative effects. It can also induce hormonal, lipid and neural changes. OBJECTIVE: To evaluate the WBC effect on cognitive functioning and blood parameters of MCI patients. MATERIALS AND METHODS: Participants with MCI undertook 10 WBC sessions. Cognitive functions and depressive symptoms were assessed before the first session, after the last session and 2 weeks later. Whole blood samples were collected. RESULTS: The cognitive functioning improved after 10 WBC sessions (p<0.05), especially memory processes. WBC caused a significant (p<0.05) increase of NO plasma level, BDNF concentration (p<0.05) and reduction of IL-6 (p<0.05). The moderate relationship between NO and cognitive functioning was noticed after WBC. CONCLUSION: The preliminary results of the first study evaluating WBC on memory deficits suggest that WBC may be useful as a supportive therapy of MCI.
BACKGROUND: Mild Cognitive Impairments (MCI) and dementia are still incurable. The Whole-Body Cryotherapy (WBC) - short, cyclic exposure to extremely low temperatures - has proven anti-inflammatory and anti-oxidative effects. It can also induce hormonal, lipid and neural changes. OBJECTIVE: To evaluate the WBC effect on cognitive functioning and blood parameters of MCI patients. MATERIALS AND METHODS:Participants with MCI undertook 10 WBC sessions. Cognitive functions and depressive symptoms were assessed before the first session, after the last session and 2 weeks later. Whole blood samples were collected. RESULTS: The cognitive functioning improved after 10 WBC sessions (p<0.05), especially memory processes. WBC caused a significant (p<0.05) increase of NO plasma level, BDNF concentration (p<0.05) and reduction of IL-6 (p<0.05). The moderate relationship between NO and cognitive functioning was noticed after WBC. CONCLUSION: The preliminary results of the first study evaluating WBC on memory deficits suggest that WBC may be useful as a supportive therapy of MCI.
Authors: Joanna Rymaszewska; Katarzyna M Lion; Lilla Pawlik-Sobecka; Tomasz Pawłowski; Dorota Szcześniak; Elżbieta Trypka; Julia E Rymaszewska; Agnieszka Zabłocka; Bartlomiej Stanczykiewicz Journal: Front Psychiatry Date: 2020-06-09 Impact factor: 4.157
Authors: Agnieszka Zembron-Lacny; Barbara Morawin; Edyta Wawrzyniak-Gramacka; Jaroslaw Gramacki; Pawel Jarmuzek; Dariusz Kotlega; Ewa Ziemann Journal: Int J Environ Res Public Health Date: 2020-10-27 Impact factor: 3.390