Inference of Cerebrovascular Topology With Geodesic Minimum Spanning Trees.

A vectorial representation of the vascular network that embodies quantitative features-location, direction, scale, and bifurcations-has many potential cardio- and neuro-vascular applications. We present VTrails, an end-to-end approach to extract geodesic vascular minimum spanning trees from angiographic data by solving a connectivity-optimized anisotropic level-set over a voxel-wise tensor field representing the orientation of the underlying vasculature. Evaluating real and synthetic vascular images, we compare VTrails against the state-of-the-art ridge detectors for tubular structures by assessing the connectedness of the vesselness map and inspecting the synthesized tensor field. The inferred geodesic trees are then quantitatively evaluated within a topologically aware framework, by comparing the proposed method against popular vascular segmentation tool kits on clinical angiographies. VTrails potentials are discussed towards integrating groupwise vascular image analyses. The performance of VTrails demonstrates its versatility and usefulness also for patient-specific applications in interventional neuroradiology and vascular surgery.