Literature DB >> 3005916

Effects of valproate on biogenesis and function of liver mitochondria.

K Hayasaka, I Takahashi, Y Kobayashi, K Iinuma, K Narisawa, K Tada.   

Abstract

The mitochondrial protein content of liver increased, and mitochondria enlarged after prolonged administration of valproic acid (VPA: N-dipropylacetic acid) to rats. The mitochondria showed low specific activities of membrane-bound enzymes, decreased content of cytochrome aa3, and decreased respiration in states 3 and 4. In vitro studies of amino acid incorporation suggested a decrease in protein synthesis in liver mitochondria from VPA-treated rats. Prolonged administration of VPA seems to impair mitochondrial structure and function.

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Year:  1986        PMID： 3005916     DOI： 10.1212/wnl.36.3.351

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  12 in total

1.  Ultrastructure of Purkinje cell perikarya and their dendritic processes in the rat cerebellar cortex in experimental encephalopathy induced by chronic application of valproate.

Authors:  M E Sobaniec-Lotowska
Journal:  Int J Exp Pathol       Date:  2001-12       Impact factor: 1.925

Review 2.  Biochemical relationships between Reye's and Reye's-like metabolic and toxicological syndromes.

Authors:  J Osterloh; W Cunningham; A Dixon; D Combest
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Jul-Aug

3.  Valproate and cytochrome c oxidase deficiency.

Authors:  S Ponchaut; F Van Hoof; K Veitch
Journal:  Eur J Pediatr       Date:  1995-01       Impact factor: 3.183

4.  Increased hepatic mitochondrial capacity in rats with hydroxy-cobalamin[c-lactam]-induced methylmalonic aciduria.

Authors:  S Krahenbuhl; D B Ray; S P Stabler; R H Allen; E P Brass
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

Review 5.  Valproate-associated hepatotoxicity and its biochemical mechanisms.

Authors:  M J Eadie; W D Hooper; R G Dickinson
Journal:  Med Toxicol Adverse Drug Exp       Date:  1988 Mar-Apr

6.  Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid.

Authors:  K Iinuma; K Hayasaka; K Narisawa; K Tada; K Hori
Journal:  Eur J Pediatr       Date:  1988-12       Impact factor: 3.183

7.  Sodium valproate inhibits the movement of secretory vesicles in rat hepatocytes.

Authors:  M E Bellringer; K Rahman; R Coleman
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

8.  Valproic acid is associated with cognitive decline in HIV-infected individuals: a clinical observational study.

Authors:  Lucette A Cysique; Paul Maruff; Bruce J Brew
Journal:  BMC Neurol       Date:  2006-12-06       Impact factor: 2.474

9.  The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome.

Authors:  Marta Kanabus; Elisa Fassone; Sean David Hughes; Sara Farahi Bilooei; Tricia Rutherford; Maura O' Donnell; Simon J R Heales; Shamima Rahman
Journal:  J Inherit Metab Dis       Date:  2016-04-14       Impact factor: 4.982

10.  Combined Transcriptomics and Chemical-Genetics Reveal Molecular Mode of Action of Valproic acid, an Anticancer Molecule using Budding Yeast Model.

Authors:  Upendarrao Golla; Deepthi Joseph; Raghuvir Singh Tomar
Journal:  Sci Rep       Date:  2016-10-13       Impact factor: 4.379
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