Literature DB >> 30058735

Prenatal myelomeningocele repair improves urinary continence and reduces the risk of constipation.

Agnieszka Pastuszka1, Janusz Bohosiewicz2, Tomasz Koszutski3.   

Abstract

AIMS: The aim of the study was to evaluate the lower urinary tract function, frequency UTI, the degree of social urine continence, and the occurrence of constipation in children who underwent prenatal or postnatal surgery for MMC.
MATERIALS AND METHODS: Seventy-two patients with MMC were assessed and divided into the prenatal group (36 patients) and the postnatal one (36 patients). All children, regardless the time of operation, received the same treatment after birth. The urodynamic tests, USG, cystourethrography were performed in all patients along with evaluation of the UTI's, social urine continence, and presence of constipation.
RESULTS: Urodynamic and imaging studies showed no differences between the test groups. Children from the prenatally operated group showed statistically significant lower number of urinary tract infections, better urine continence, and less frequent constipation.
CONCLUSIONS: Prenatal MMC repair ensures statistically significant improvement of the degree of social urinary continence, reducing the risk of urinary infections and constipation. Time of MMC repair does not statistically influence the urodynamic tests results and the urodynamic parameters are not the prognostic elements to assess the social urinary continence possibility in patients with the neurogenic bladder.
© 2018 Wiley Periodicals, Inc.

Entities:  

Keywords:  melomeningocele; neurogenic bladder and bowel; prenatal surgery

Mesh:

Year:  2018        PMID: 30058735     DOI: 10.1002/nau.23771

Source DB:  PubMed          Journal:  Neurourol Urodyn        ISSN: 0733-2467            Impact factor:   2.696


  4 in total

Review 1.  Fetal myelomeningocele repair: a narrative review of the history, current controversies and future directions.

Authors:  Kaeli J Yamashiro; Diana L Farmer
Journal:  Transl Pediatr       Date:  2021-05

Review 2.  Understanding Sociodemographic Disparities in Maternal-Fetal Surgery Study Participation.

Authors:  Abigail Wilpers; Anna Y Lynn; Barbara Eichhorn; Amy B Powne; Megan Lagueux; Janene Batten; Mert Ozan Bahtiyar; Cary P Gross
Journal:  Fetal Diagn Ther       Date:  2022-03-10       Impact factor: 2.208

3.  Preclinical stem cell therapy in fetuses with myelomeningocele: A systematic review and meta-analysis.

Authors:  Yada Kunpalin; Sindhu Subramaniam; Silvia Perin; Mattia F M Gerli; Jan Bosteels; Sebastien Ourselin; Jan Deprest; Paolo De Coppi; Anna L David
Journal:  Prenat Diagn       Date:  2021-01-11       Impact factor: 3.242

4.  In utero myelomeningocele repair reduces intensification of inflammatory changes in the dura mater and the skin.

Authors:  Agnieszka Pastuszka; Janusz Bohosiewicz; Anita Olejek; Jacek Zamłyński; Ewa Horzelska; Tomasz Koszutski
Journal:  J Spinal Cord Med       Date:  2020-03-30       Impact factor: 1.985

  4 in total

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