| Literature DB >> 30057355 |
Yasser Hussein Eissa Mohammed1, H M Manukumar2, K P Rakesh3, C S Karthik2, P Mallu4, Hua-Li Qin5.
Abstract
The Staphylococcus aureus biofilm-associated burden is challenging to the field of medicine to eradicate or avoid it. Even though a number of S. aureus biofilm mechanisms understood and established the possible ways of biofilm formation but, still need to know more and require a development of new therapeutic strategies. In this viewpoint, we discuss the underlining biofilm mechanism, its existing systems as active therapeutic agents and as vehicles to transport drugs to the site of infection. The step-back in drug development is due to the emergence of antibiotic-resistant S. aureus. The understanding of bacteria/biofilms is an aspect that we likewise summarize for possible drug development for future as medicine against resistant S. aureus was viewed.Entities:
Keywords: Anti-Biofilm; Drug development; Mechanism; Staphylococcus aureus
Mesh：
Substances：
Year: 2018 PMID： 30057355 DOI： 10.1016/j.micpath.2018.07.002
Source DB: PubMed Journal: Microb Pathog ISSN： 0882-4010 Impact factor: 3.738