Literature DB >> 30057145

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma.

Masao Nakagawa1, Arthur L Shaffer2, Michele Ceribelli3, Meili Zhang2, George Wright4, Da Wei Huang2, Wenming Xiao5, John Powell6, Michael N Petrus2, Yibin Yang7, James D Phelan2, Holger Kohlhammer2, Sigrid P Dubois2, Hee Min Yoo2, Emmanuel Bachy2, Daniel E Webster2, Yandan Yang2, Weihong Xu2, Xin Yu2, Hong Zhao2, Bonita R Bryant2, Joji Shimono8, Takashi Ishio8, Michiyuki Maeda9, Patrick L Green10, Thomas A Waldmann11, Louis M Staudt12.   

Abstract

Adult T cell leukemia/lymphoma (ATLL) is a frequently incurable disease associated with the human lymphotropic virus type I (HTLV-I). RNAi screening of ATLL lines revealed that their proliferation depends on BATF3 and IRF4, which cooperatively drive ATLL-specific gene expression. HBZ, the only HTLV-I encoded transcription factor that is expressed in all ATLL cases, binds to an ATLL-specific BATF3 super-enhancer and thereby regulates the expression of BATF3 and its downstream targets, including MYC. Inhibitors of bromodomain-and-extra-terminal-domain (BET) chromatin proteins collapsed the transcriptional network directed by HBZ and BATF3, and were consequently toxic for ATLL cell lines, patient samples, and xenografts. Our study demonstrates that the HTLV-I oncogenic retrovirus exploits a regulatory module that can be attacked therapeutically with BET inhibitors. Published by Elsevier Inc.

Entities:  

Keywords:  ATLL; BATF3; BET inhibitor; HBZ; functional genomics

Mesh：

Substances：

Year:  2018        PMID： 30057145      PMCID： PMC8078141          DOI： 10.1016/j.ccell.2018.06.014

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  39 in total

1.  Identification and characterization of essential genes in the human genome.

Authors:  Tim Wang; Kıvanç Birsoy; Nicholas W Hughes; Kevin M Krupczak; Yorick Post; Jenny J Wei; Eric S Lander; David M Sabatini
Journal:  Science       Date:  2015-10-15       Impact factor: 47.728

2.  Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.

Authors:  Georg Lenz; R Eric Davis; Vu N Ngo; Lloyd Lam; Thaddeus C George; George W Wright; Sandeep S Dave; Hong Zhao; Weihong Xu; Andreas Rosenwald; German Ott; Hans Konrad Muller-Hermelink; Randy D Gascoyne; Joseph M Connors; Lisa M Rimsza; Elias Campo; Elaine S Jaffe; Jan Delabie; Erlend B Smeland; Richard I Fisher; Wing C Chan; Louis M Staudt
Journal:  Science       Date:  2008-03-06       Impact factor: 47.728

Review 3.  Adult T-cell Leukemia/Lymphoma: A Problem Abroad and at Home.

Authors:  Christopher Dittus; J Mark Sloan
Journal:  Hematol Oncol Clin North Am       Date:  2017-04       Impact factor: 3.722

4.  High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities.

Authors:  Traver Hart; Megha Chandrashekhar; Michael Aregger; Zachary Steinhart; Kevin R Brown; Graham MacLeod; Monika Mis; Michal Zimmermann; Amelie Fradet-Turcotte; Song Sun; Patricia Mero; Peter Dirks; Sachdev Sidhu; Frederick P Roth; Olivia S Rissland; Daniel Durocher; Stephane Angers; Jason Moffat
Journal:  Cell       Date:  2015-11-25       Impact factor: 41.582

5.  Use of zidovudine and interferon alfa with chemotherapy improves survival in both acute and lymphoma subtypes of adult T-cell leukemia/lymphoma.

Authors:  Andrew Hodson; Siobhan Crichton; Silvia Montoto; Naheed Mir; Estella Matutes; Kate Cwynarski; Thurai Kumaran; Kirit M Ardeshna; Antonio Pagliuca; Graham P Taylor; Paul A Fields
Journal:  J Clin Oncol       Date:  2011-10-31       Impact factor: 44.544

6.  Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma.

Authors:  Yibin Yang; Arthur L Shaffer; N C Tolga Emre; Michele Ceribelli; Meili Zhang; George Wright; Wenming Xiao; John Powell; John Platig; Holger Kohlhammer; Ryan M Young; Hong Zhao; Yandan Yang; Weihong Xu; Joseph J Buggy; Sriram Balasubramanian; Lesley A Mathews; Paul Shinn; Rajarshi Guha; Marc Ferrer; Craig Thomas; Thomas A Waldmann; Louis M Staudt
Journal:  Cancer Cell       Date:  2012-06-12       Impact factor: 31.743

7.  Master transcription factors and mediator establish super-enhancers at key cell identity genes.

Authors:  Warren A Whyte; David A Orlando; Denes Hnisz; Brian J Abraham; Charles Y Lin; Michael H Kagey; Peter B Rahl; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2013-04-11       Impact factor: 41.582

8.  Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data.

Authors:  Robert C McLeay; Timothy L Bailey
Journal:  BMC Bioinformatics       Date:  2010-04-01       Impact factor: 3.169

9.  BATF-JUN is critical for IRF4-mediated transcription in T cells.

Authors:  Peng Li; Rosanne Spolski; Wei Liao; Lu Wang; Theresa L Murphy; Kenneth M Murphy; Warren J Leonard
Journal:  Nature       Date:  2012-09-19       Impact factor: 49.962

Review 10.  Recent Advances in Therapeutic Approaches for Adult T-cell Leukemia/Lymphoma.

Authors:  Koji Kato; Koichi Akashi
Journal:  Viruses       Date:  2015-12-14       Impact factor: 5.048
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  31 in total

Review 1.  Dissecting Tissue-Specific Super-Enhancers by Integrating Genome-Wide Analyses and CRISPR/Cas9 Genome Editing.

Authors:  Kyung Hyun Yoo; Lothar Hennighausen; Ha Youn Shin
Journal:  J Mammary Gland Biol Neoplasia       Date:  2018-10-06       Impact factor: 2.673

2.  A novel model of controlling PD-L1 expression in ALK+ anaplastic large cell lymphoma revealed by CRISPR screening.

Authors:  Jing-Ping Zhang; Zhihui Song; Hong-Bo Wang; Lang Lang; Yuan-Zhong Yang; Wenming Xiao; Daniel E Webster; Wei Wei; Stefan K Barta; Marshall E Kadin; Louis M Staudt; Masao Nakagawa; Yibin Yang
Journal:  Blood       Date:  2019-05-31       Impact factor: 22.113

Review 3.  Molecular biology of human T cell leukemia virus.

Authors:  Lee Ratner
Journal:  Semin Diagn Pathol       Date:  2019-04-16       Impact factor: 3.464

4.  BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models.

Authors:  Xiaohong Zhao; Yuan Ren; Matthew Lawlor; Bijal D Shah; Paul M C Park; Tint Lwin; Xuefeng Wang; Kenian Liu; Michelle Wang; Jing Gao; Tao Li; Mousheng Xu; Ariosto S Silva; Kaplan Lee; Tinghu Zhang; John M Koomen; Huijuan Jiang; Praneeth R Sudalagunta; Mark B Meads; Fengdong Cheng; Chengfeng Bi; Kai Fu; Huitao Fan; William S Dalton; Lynn C Moscinski; Kenneth H Shain; Eduardo M Sotomayor; Gang Greg Wang; Nathanael S Gray; John L Cleveland; Jun Qi; Jianguo Tao
Journal:  Cancer Cell       Date:  2019-05-13       Impact factor: 31.743

5.  Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Upregulates the Expression of ICAM-1 To Facilitate HTLV-1 Infection.

Authors:  Ana Laura Fazio; Wesley Kendle; Kimson Hoang; Erica Korleski; Isabelle Lemasson; Nicholas Polakowski
Journal:  J Virol       Date:  2019-09-12       Impact factor: 5.103

6.  Genome-wide CRISPR screen identifies CDK6 as a therapeutic target in adult T-cell leukemia/lymphoma.

Authors:  Takashi Ishio; Sarvesh Kumar; Joji Shimono; Anusara Daenthanasanmak; Sigrid Dubois; Yuquan Lin; Bonita Bryant; Michael N Petrus; Emmanuel Bachy; Da Wei Huang; Yandan Yang; Patrick L Green; Hiroo Hasegawa; Michiyuki Maeda; Hideki Goto; Tomoyuki Endo; Takashi Yokota; Kanako C Hatanaka; Yutaka Hatanaka; Shinya Tanaka; Yoshihiro Matsuno; Yibin Yang; Satoshi Hashino; Takanori Teshima; Thomas A Waldmann; Louis M Staudt; Masao Nakagawa
Journal:  Blood       Date:  2022-03-10       Impact factor: 22.113

7.  Requirement for TP73 and genetic alterations originating from its intragenic super-enhancer in adult T-cell leukemia.

Authors:  Jolynn Zu Lin Ong; Rui Yokomori; Regina Wan Ju Wong; Tze King Tan; Ryuzo Ueda; Takashi Ishida; Shinsuke Iida; Takaomi Sanda
Journal:  Leukemia       Date:  2022-07-30       Impact factor: 12.883

Review 8.  Updates in lymph node and skin pathology of adult T-cell leukemia/lymphoma, biomarkers, and beyond.

Authors:  Brian D Adkins; Juan C Ramos; Meghan Bliss-Moreau; Alejandro A Gru
Journal:  Semin Diagn Pathol       Date:  2019-12-20       Impact factor: 3.464

9.  The splice 1 variant of HTLV-1 bZIP factor stabilizes c-Jun.

Authors:  Nicholas Polakowski; Martin Pearce; Oppah Kuguyo; Georgina Boateng; Kimson Hoang; Isabelle Lemasson
Journal:  Virology       Date:  2020-08-09       Impact factor: 3.616

10.  Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma.

Authors:  Anusara Daenthanasanmak; Richard N Bamford; Makoto Yoshioka; Shyh-Ming Yang; Philip Homan; Baktiar Karim; Bonita R Bryant; Michael N Petrus; Craig J Thomas; Patrick L Green; Milos D Miljkovic; Kevin C Conlon; Thomas A Waldmann
Journal:  Blood Adv       Date:  2022-04-12
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