| Literature DB >> 30056057 |
Asma Nafisa1, Susan G Gray2, Yingnan Cao3, Tinghuai Wang4, Suowen Xu5, Feroza H Wattoo6, Michael Barras7, Neale Cohen8, Danielle Kamato9, Peter J Little10.
Abstract
Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a timely review on the protective effects and molecular mechanisms of metformin in preventing endothelial dysfunction and cardiovascular and metabolic diseases.Entities:
Keywords: CVD; Endothelial dysfunction; Endothelium; Hyperglycaemia; Mechanism of action; Metformin
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Year: 2018 PMID： 30056057 DOI： 10.1016/j.pharmthera.2018.07.007
Source DB: PubMed Journal: Pharmacol Ther ISSN： 0163-7258 Impact factor: 12.310