| Literature DB >> 3005578 |
L D Markley, Y C Tong, J K Dulworth, D L Steward, C T Goralski, H Johnston, S G Wood, A P Vinogradoff, T M Bargar.
Abstract
Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given orally prior to and during infection protected mice against an otherwise lethal challenge with coxsackievirus A21.Entities:
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Year: 1986 PMID： 3005578 DOI： 10.1021/jm00153a020
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446