Literature DB >> 30055053

Phase waves and trigger waves: emergent properties of oscillating and excitable networks in the gut.

Sean P Parsons1, Jan D Huizinga1.   

Abstract

The gut is enmeshed by a number of cellular networks, but there is only a limited understanding of how these networks generate the complex patterns of activity that drive gut contractile functions. Here we review two fundamental types of cell behaviour, excitable and oscillating, and the patterns that networks of such cells generate, trigger waves and phase waves, respectively. We use both the language of biophysics and the theory of nonlinear dynamics to define these behaviours and understand how they generate patterns. Based on this we look for evidence of trigger and phase waves in the gut, including some of our recent work on the small intestine.
© 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.

Keywords:  Gastrointestinal Motility; ICC; Interstitial cells of Cajal; non-linear dynamics; pacemaker networks; phase waves; trigger waves

Mesh:

Year:  2018        PMID: 30055053      PMCID: PMC6187044          DOI: 10.1113/JP273425

Source DB:  PubMed          Journal:  J Physiol        ISSN: 0022-3751            Impact factor:   5.182


  50 in total

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9.  Biophysically based modeling of the interstitial cells of cajal: current status and future perspectives.

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Review 10.  Progress in Mathematical Modeling of Gastrointestinal Slow Wave Abnormalities.

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Journal:  Front Physiol       Date:  2018-01-15       Impact factor: 4.566

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  4 in total

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Journal:  Front Neurosci       Date:  2021-01-07       Impact factor: 4.677

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Journal:  J Smooth Muscle Res       Date:  2019

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Authors:  Sean P Parsons; Jan D Huizinga
Journal:  Sci Rep       Date:  2020-09-15       Impact factor: 4.379

  4 in total

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