Juan Manuel Sánchez-Hidalgo1, Sebastián Rufián-Peña1, Manuel Durán-Martínez2, Álvaro Arjona-Sánchez1, Inmaculada Salcedo-Leal3, Pedro Lopez-Cillero4, Javier Briceño-Delgado4. 1. Unidad de Cirugía Oncológica, Unidad de Cirugía General y del Aparato Digestivo, Hospital Universitario Reina Sofía, Córdoba, España. 2. Unidad de Cirugía Oncológica, Unidad de Cirugía General y del Aparato Digestivo, Hospital Universitario Reina Sofía, Córdoba, España. Electronic address: manuduma@hotmail.com. 3. Unidad de Medicina Preventiva, Hospital Universitario Reina Sofía, Córdoba, España. 4. Unidad de Cirugía Hepatobiliar, Unidad de Cirugía General y del Aparato Digestivo, Hospital Universitario Reina Sofía, Córdoba, España.
Abstract
INTRODUCTION: The aim of this study is to identify factors associated to recurrence and survival in primary retroperitoneal liposarcomas. METHODS: Prospective database of 35 patients with primary retroperitoneal liposarcoma treated 2004-2015 were retrospectively analyzed. Exclusion criteria were recurrent and metastatic tumors. Overall survival (OS) and disease-free survival were reviewed. Patient data were compared between patients with or without recurrence within 12 months after surgery. Risk factors were determined using logistic regression analysis. RESULTS: Five-year OS was 61.1%. One and three-year disease-free survival were 68.6% and 17.1% respectively. OS in the early recurrence group was 36.4 months compared with 43.2 months in the group without early recurrence (P=.011). Early recurrence was associated with a reduction in OS (HR=4.05; CI95%: 1.27-12.96; P=.018). Multifocality and microscopic positive margins R1 were associated with early recurrence. Histologic subtype, margin of resection, histologic grade and multifocality were factors associated with recurrence. Contiguously involved organ resection had a beneficial effect on early recurrence and was associated with an increase in disease-free survival and OS. Adjuvant treatments had no protective effect on recurrence. CONCLUSIONS: This study underlines the crucial role aggressive surgical approach in retroperitoneal Liposarcoma treatment, especially in those patients with histological characteristics that adversely the prognosis.
INTRODUCTION: The aim of this study is to identify factors associated to recurrence and survival in primary retroperitoneal liposarcomas. METHODS: Prospective database of 35 patients with primary retroperitoneal liposarcoma treated 2004-2015 were retrospectively analyzed. Exclusion criteria were recurrent and metastatic tumors. Overall survival (OS) and disease-free survival were reviewed. Patient data were compared between patients with or without recurrence within 12 months after surgery. Risk factors were determined using logistic regression analysis. RESULTS: Five-year OS was 61.1%. One and three-year disease-free survival were 68.6% and 17.1% respectively. OS in the early recurrence group was 36.4 months compared with 43.2 months in the group without early recurrence (P=.011). Early recurrence was associated with a reduction in OS (HR=4.05; CI95%: 1.27-12.96; P=.018). Multifocality and microscopic positive margins R1 were associated with early recurrence. Histologic subtype, margin of resection, histologic grade and multifocality were factors associated with recurrence. Contiguously involved organ resection had a beneficial effect on early recurrence and was associated with an increase in disease-free survival and OS. Adjuvant treatments had no protective effect on recurrence. CONCLUSIONS: This study underlines the crucial role aggressive surgical approach in retroperitoneal Liposarcoma treatment, especially in those patients with histological characteristics that adversely the prognosis.
Authors: Benjamin Paik; Chin Jin Seo; Joey Wee-Shan Tan; Wen Kai Darryl Juan; Khee Chee Soo; Chin-Ann Johnny Ong; Claramae Shulyn Chia; Jolene Si Min Wong Journal: Front Oncol Date: 2022-08-11 Impact factor: 5.738