Bryan Williams1, Morris J Brown2. 1. UCL Institute of Cardiovascular Sciences, University College London, London, UK; National Institute for Health Research, UCL Hospitals Biomedical Research Centre, London, UK. 2. William Harvey Research Institute, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Hospital Biomedical Research Centre, London, UK. Electronic address: morris.brown@qmul.ac.uk.