Noriane A Sievi1, Thomas Brack2, Martin H Brutsche3, Martin Frey4, Sarosh Irani5, Jörg D Leuppi6, Robert Thurnheer7, Malcolm Kohler8, Christian F Clarenbach9. 1. Pulmonary Division, University Hospital Zurich, Switzerland. 2. Pulmonary Division, Cantonal Hospital of Glarus, Switzerland. 3. Pulmonary Division, Cantonal Hospital of St. Gallen, Switzerland. 4. Pulmonary Division, Clinic Barmelweid, Switzerland. 5. Pulmonary Division, Cantonal Hospital of Aarau, Switzerland. 6. University Department of Medicine, Cantonal Hospital Baselland and University of Basel, Switzerland. 7. Pulmonary Division, Cantonal Hospital of Münsterlingen, Switzerland. 8. Pulmonary Division, University Hospital Zurich, Switzerland; Zurich Centre for Integrative Human Physiology, University of Zurich, Switzerland. 9. Pulmonary Division, University Hospital Zurich, Switzerland. Electronic address: christian.clarenbach@usz.ch.
Abstract
BACKGROUND AND OBJECTIVE: Daily physical activity (PA) and exercise capacity are reduced in patients with COPD. Whether the natural longitudinal course of both appears synchronically or one precedes the other is currently unclear. The aim was to assess the longitudinal relationship between exercise capacity and physical activity and their changes over time in patients with COPD. METHODS: In a longitudinal observation-study of heterogeneous COPD patients, recruited from pulmonary outpatient clinics or hospital settings, we annually investigated two exercise capacity tests (1-min sit to stand test (STS) and 6 min walking test (6MWT)) and daily physical activity assessed by number of steps per day for minimum one, up to seven years. Univariable and multivariable mixed effect models were used to investigate the annual change in STS, 6MWD and number of steps per day. RESULTS: 202 COPD patients (17% COPD risk group (considers symptoms and future exacerbation risk to grade disease severity) A, 49% B, 4% C and 34% D) with a mean (min/max) follow-up time of 2.4 (0.9/6.8) years were annually assessed. The number of steps per day decreased significantly over time (annual mean (95% CI) of -451.0 (-605.3/-296.6) steps, p < 0.001) while STS and 6MWD remained stable. CONCLUSION: Our findings suggest that COPD patients are increasingly impaired in their daily PA while exercise capacity remains stable during the study period. Thus, the longitudinal decline in PA seems not to be explained by a concomitant reduction in exercise tolerance. CLINICAL TRIAL REGISTRATION: www.Clinicaltrials.Gov, NCT01527773.
BACKGROUND AND OBJECTIVE: Daily physical activity (PA) and exercise capacity are reduced in patients with COPD. Whether the natural longitudinal course of both appears synchronically or one precedes the other is currently unclear. The aim was to assess the longitudinal relationship between exercise capacity and physical activity and their changes over time in patients with COPD. METHODS: In a longitudinal observation-study of heterogeneous COPDpatients, recruited from pulmonary outpatient clinics or hospital settings, we annually investigated two exercise capacity tests (1-min sit to stand test (STS) and 6 min walking test (6MWT)) and daily physical activity assessed by number of steps per day for minimum one, up to seven years. Univariable and multivariable mixed effect models were used to investigate the annual change in STS, 6MWD and number of steps per day. RESULTS: 202 COPDpatients (17% COPD risk group (considers symptoms and future exacerbation risk to grade disease severity) A, 49% B, 4% C and 34% D) with a mean (min/max) follow-up time of 2.4 (0.9/6.8) years were annually assessed. The number of steps per day decreased significantly over time (annual mean (95% CI) of -451.0 (-605.3/-296.6) steps, p < 0.001) while STS and 6MWD remained stable. CONCLUSION: Our findings suggest that COPDpatients are increasingly impaired in their daily PA while exercise capacity remains stable during the study period. Thus, the longitudinal decline in PA seems not to be explained by a concomitant reduction in exercise tolerance. CLINICAL TRIAL REGISTRATION: www.Clinicaltrials.Gov, NCT01527773.
Authors: Emily S Wan; Ana Kantorowski; Madeline Polak; Reema Kadri; Caroline R Richardson; David R Gagnon; Eric Garshick; Marilyn L Moy Journal: Respir Med Date: 2020-01-11 Impact factor: 3.415
Authors: Afroditi K Boutou; Yogini Raste; Heleen Demeyer; Thierry Troosters; Michael I Polkey; Ioannis Vogiatzis; Zafeiris Louvaris; Roberto A Rabinovich; Thys van der Molen; Judith Garcia-Aymerich; Nicholas S Hopkinson Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-09-03
Authors: Noriane A Sievi; Thomas Brack; Martin H Brutsche; Martin Frey; Sarosh Irani; Jörg D Leuppi; Robert Thurnheer; Malcolm Kohler; Christian F Clarenbach Journal: Respir Res Date: 2020-01-20