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Literature DB >> 30053951

Inconvenient Truth to Principle of Neuroscience.

Abstract

In 2004, Prinz et al. demonstrated that almost indistinguishable network activity can arise from widely different sets of underlying membrane and synaptic parameters, and, thus, likely arise from different cellular and network mechanisms. This now broadly accepted principle guides research into individual variation in neuronal and synaptic properties, and their homeostatic regulation.

Entities: Chemical Disease

Keywords: conductance parameter sets; homeostasis; network stability; neuronal models

Year: 2018 PMID： 30053951 PMCID： PMC6065260 DOI： 10.1016/j.tins.2018.05.006

Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837

15 in total

1. Activity-dependent regulation of potassium currents in an identified neuron of the stomatogastric ganglion of the crab Cancer borealis.

Authors: J Golowasch; L F Abbott; E Marder
Journal: J Neurosci Date: 1999-10-15 Impact factor: 6.167

2. Failure of averaging in the construction of a conductance-based neuron model.

Authors: Jorge Golowasch; Mark S Goldman; L F Abbott; Eve Marder
Journal: J Neurophysiol Date: 2002-02 Impact factor: 2.714

Review 3. Modeling stability in neuron and network function: the role of activity in homeostasis.

Authors: Eve Marder; Astrid A Prinz
Journal: Bioessays Date: 2002-12 Impact factor: 4.345

4. Ca²⁺/cAMP-sensitive covariation of I(A) and I(H) voltage dependences tunes rebound firing in dopaminergic neurons.

Authors: Julien Amendola; Adele Woodhouse; Marie-France Martin-Eauclaire; Jean-Marc Goaillard
Journal: J Neurosci Date: 2012-02-08 Impact factor: 6.167

5. Similar network activity from disparate circuit parameters.

Authors: Astrid A Prinz; Dirk Bucher; Eve Marder
Journal: Nat Neurosci Date: 2004-11-21 Impact factor: 24.884

6. Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression.

Authors: David J Schulz; Jean-Marc Goaillard; Eve E Marder
Journal: Proc Natl Acad Sci U S A Date: 2007-07-25 Impact factor: 11.205

Inconvenient Truth to Principle of Neuroscience.

1. Activity-dependent regulation of potassium currents in an identified neuron of the stomatogastric ganglion of the crab Cancer borealis.

2. Failure of averaging in the construction of a conductance-based neuron model.

Review 3. Modeling stability in neuron and network function: the role of activity in homeostasis.

4. Ca²⁺/cAMP-sensitive covariation of I(A) and I(H) voltage dependences tunes rebound firing in dopaminergic neurons.

5. Similar network activity from disparate circuit parameters.

6. Quantitative expression profiling of identified neurons reveals cell-specific constraints on highly variable levels of gene expression.

7. Correlations in ion channel expression emerge from homeostatic tuning rules.

8. Selective regulation of current densities underlies spontaneous changes in the activity of cultured neurons.

9. Functional consequences of animal-to-animal variation in circuit parameters.

10. Output variability across animals and levels in a motor system.

1. Visualization of currents in neural models with similar behavior and different conductance densities.

2. Network architectures supporting learnability.