Literature DB >> 30052876

A yeast for all seasons - Is Pichia pastoris a suitable chassis organism for future bioproduction?

Brigitte Gasser1,2,3, Diethard Mattanovich1,2.   

Abstract

The methylotrophic yeast Pichia pastoris (Komagataella spp.) is well established as a host for recombinant protein production. Since a few years it has also been subject to metabolic engineering to produce a diversity of biochemicals. Based on these developments we discuss here why P. pastoris is a suitable future chassis organism for synthetic biology, and we provide a roadmap for a community effort towards this aim.

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Year:  2018        PMID： 30052876     DOI： 10.1093/femsle/fny181

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  6 in total

1.  Contextualized genome-scale model unveils high-order metabolic effects of the specific growth rate and oxygenation level in recombinant Pichia pastoris.

Authors:  Paulina Torres; Pedro A Saa; Joan Albiol; Pau Ferrer; Eduardo Agosin
Journal:  Metab Eng Commun       Date:  2019-10-14

2.  A programmable high-expression yeast platform responsive to user-defined signals.

Authors:  Qi Liu; Lili Song; Qiangqiang Peng; Qiaoyun Zhu; Xiaona Shi; Mingqiang Xu; Qiyao Wang; Yuanxing Zhang; Menghao Cai
Journal:  Sci Adv       Date:  2022-02-11       Impact factor: 14.136

3.  Bioreactor-scale cell performance and protein production can be substantially increased by using a secretion signal that drives co-translational translocation in Pichia pastoris.

Authors:  Juan J Barrero; Alejandro Pagazartaundua; Benjamin S Glick; Francisco Valero; Pau Ferrer
Journal:  N Biotechnol       Date:  2020-10-09       Impact factor: 5.079

4.  YEASTRACT+: a portal for cross-species comparative genomics of transcription regulation in yeasts.

Authors:  Pedro T Monteiro; Jorge Oliveira; Pedro Pais; Miguel Antunes; Margarida Palma; Mafalda Cavalheiro; Mónica Galocha; Cláudia P Godinho; Luís C Martins; Nuno Bourbon; Marta N Mota; Ricardo A Ribeiro; Romeu Viana; Isabel Sá-Correia; Miguel C Teixeira
Journal:  Nucleic Acids Res       Date:  2020-01-08       Impact factor: 16.971

5.  Screening for functional IRESes using α-complementation system of β-galactosidase in Pichia pastoris.

Authors:  Yide Huang; Yafei Zhang; Suhuan Li; Ting Lin; Jingwen Wu; Yao Lin
Journal:  Biotechnol Biofuels       Date:  2019-12-27       Impact factor: 6.040

Review 6.  Multiplex Genome Engineering Methods for Yeast Cell Factory Development.

Authors:  Koray Malcı; Laura E Walls; Leonardo Rios-Solis
Journal:  Front Bioeng Biotechnol       Date:  2020-10-29
  6 in total

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