Literature DB >> 30052285

Long noncoding RNAs and their epigenetic function in hematological diseases.

Hanying Huang1, Jingnan Sun1,2, Yunpeng Sun3, Cong Wang1,2, Sujun Gao1, Wei Li1, Ji-Fan Hu1,2.   

Abstract

Recent discoveries demonstrate the importance of long noncoding RNA (lncRNA) in the regulation of multiple major processes impacting development, differentiation, and metastasis of hematological diseases through epigenetic mechanisms. In contrast to genetic changes, epigenetic modification does not modify genes but is frequently reversible, thus providing opportunities for targeted treatment using specific inhibitors. In this review, we will summarize the function and epigenetic mechanism of lncRNA in malignant hematologic diseases.
© 2018 John Wiley & Sons, Ltd.

Entities:  

Keywords:  epigenetics; long noncoding RNA; malignant hematological diseases

Mesh：

Substances：

Year:  2018        PMID： 30052285     DOI： 10.1002/hon.2534

Source DB:  PubMed          Journal:  Hematol Oncol        ISSN： 0278-0232            Impact factor:   5.271


  6 in total

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2.  Pluripotency exit is guided by the Peln1-mediated disruption of intrachromosomal architecture.

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Journal:  J Cell Biol       Date:  2022-02-16       Impact factor: 8.077

3.  Intrachromosomal Looping and Histone K27 Methylation Coordinately Regulates the lncRNA H19-Fetal Mitogen IGF2 Imprinting Cluster in the Decidual Microenvironment of Early Pregnancy.

Authors:  Xue Wen; Qi Zhang; Lei Zhou; Zhaozhi Li; Xue Wei; Wang Yang; Jiaomei Zhang; Hui Li; Zijun Xu; Xueling Cui; Songling Zhang; Yufeng Wang; Wei Li; Andrew R Hoffman; Zhonghui Liu; Ji-Fan Hu; Jiuwei Cui
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4.  Osblr8 orchestrates intrachromosomal loop structure required for maintaining stem cell pluripotency.

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5.  Identification and Validation of a Potential Prognostic 7-lncRNA Signature for Predicting Survival in Patients with Multiple Myeloma.

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Review 6.  Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells.

Authors:  Leila Yousefi; Hamid Owaysee Osquee; Reza Ghotaslou; Mohammad Ahangarzadeh Rezaee; Tahereh Pirzadeh; Javid Sadeghi; Fatemeh Hemmati; Bahman Yousefi; Seyyed Yaghoub Moaddab; Mehdi Yousefi; Masoud Shirmohammadi; Mohammad Hossein Somi; Khudaverdi Ganbarov; Hossein Samadi Kafil
Journal:  Biomed Res Int       Date:  2021-07-09       Impact factor: 3.411
  6 in total

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