Mao-Ying Lin1,2, Chrang-Shi Lin3,4, Sindy Hu1,2,5, Juo-Mei Chang2,6, Wen-Hung Chung1,7, Zhi-Yang Zhang1, Sheng-Cheng Chang1, Yu-Ping Huo1. 1. a Department of Dermatology , Xiamen Chang Gung Hospital , Xiamen , Fujian , China. 2. b Medical Cosmetic and Laser center , Xiamen Chang Gung Hospital , Xiamen , Fujian , China. 3. c Department of Dermatology and Family Medicine, National Yang-Ming University , Taipei , Taiwan. 4. d Dr. Lin Skin Clinic , Taipei , Taiwan. 5. e Department of Dermatology, Chang Gung Memorial Hospital , Chang Gung University , Taoyuan , Taiwan. 6. f Department of Plastic and Reconstructive surgery , Xiamen Chang Gung Hospital , Xiamen , Fujian , China. 7. g Department of Dermatology , Chang Gung Memorial Hospital , Linkou , Taiwan.
Abstract
BACKGROUND: The 595-nm pulsed dye laser (PDL) has been used to treat vascular anomalies for about 30 years; however, there are insufficient data in Chinese patients concerning therapeutic efficacy, optimized parameters, and procedure techniques. OBJECTIVE: To study the efficacy and relevant factors in PDL therapy for vascular anomalies in Chinese patients. METHOD: We enrolled 431 patients with 8 different vascular anomalies and no previous treatment in this retrospective study. A detailed classification of vascular anomalies and various parameters and techniques of PDL were studied. The clinical outcomes were analysed using the Investigator Global Assessment. RESULTS: Improvements were significantly correlated with infantile haemangioma (IH) subtypes (p < 0.05). A significant correlation between efficacy and lesion colour, anatomical sites, and hypertrophic-type port-wine stain (PWS) was found (p < 0.05). There was no significant correlation between efficacy and age or sex (p > 0.05). CONCLUSION: PDL is an effective and safe therapeutic modality for managing vascular anomalies in Chinese patients. We determined that differentiating and identifying IH subtypes prior to treatment could be a useful parameter for predicting therapeutic results. Lesion colour, sites, and hypertrophic changes in PWS are relevant therapeutic factors. PDL parameters and techniques differ according to the various vascular anomalies to achieve optimal results.
BACKGROUND: The 595-nm pulsed dye laser (PDL) has been used to treat vascular anomalies for about 30 years; however, there are insufficient data in Chinese patients concerning therapeutic efficacy, optimized parameters, and procedure techniques. OBJECTIVE: To study the efficacy and relevant factors in PDL therapy for vascular anomalies in Chinese patients. METHOD: We enrolled 431 patients with 8 different vascular anomalies and no previous treatment in this retrospective study. A detailed classification of vascular anomalies and various parameters and techniques of PDL were studied. The clinical outcomes were analysed using the Investigator Global Assessment. RESULTS: Improvements were significantly correlated with infantile haemangioma (IH) subtypes (p < 0.05). A significant correlation between efficacy and lesion colour, anatomical sites, and hypertrophic-type port-wine stain (PWS) was found (p < 0.05). There was no significant correlation between efficacy and age or sex (p > 0.05). CONCLUSION: PDL is an effective and safe therapeutic modality for managing vascular anomalies in Chinese patients. We determined that differentiating and identifying IH subtypes prior to treatment could be a useful parameter for predicting therapeutic results. Lesion colour, sites, and hypertrophic changes in PWS are relevant therapeutic factors. PDL parameters and techniques differ according to the various vascular anomalies to achieve optimal results.
Authors: Igor Snast; Moshe Lapidoth; Ran Kaftory; Adi Nosrati; Emmilia Hodak; Daniel Mimouni; Efrat Solomon-Cohen; Assi Levi Journal: Lasers Med Sci Date: 2021-02-13 Impact factor: 3.161