| Literature DB >> 3005069 |
Abstract
The association of the murine alpha-globin gene with the nuclear matrix was studied in three different states of the gene: inactive (EAT cells), potentially active (MEL cells) and active (induced MEL cells). When "native" nuclei were digested with DNase I it was found that the nuclear matrix was not enriched in alpha-globin DNA sequences in all three different types of cells. A nuclease-hypersensitive site in the 5'-flanking region of the alpha-globin gene was detected in the induced MEL-cells.Entities:
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Year: 1986 PMID： 3005069 DOI： 10.1016/0020-711x(86)90148-5
Source DB: PubMed Journal: Int J Biochem ISSN： 0020-711X