Literature DB >> 3005002

Serotonin 5-HT1 receptors mediate inhibition of cyclic AMP production in neurons.

S Weiss, M Sebben, D E Kemp, J Bockaert.   

Abstract

In purified striatal and cortical neurons in primary culture, serotonin (5-HT) stimulated basal cyclic AMP production (EC50, 0.5 microM) 2.5- and 1.5-fold, respectively. The 5-HT1 selective agonists, RU 24969 and 8-hydroxy-2-(di-n-propylamino)tetralin (PAT), did not stimulate cyclic AMP production. However, 5-HT, RU 24969 and PAT inhibited VIP-stimulated cyclic AMP formation in a dose-dependent manner. The actions of selective agonists and antagonists at 5-HT receptors mediating attenuation of cyclic AMP production suggest that they may be of the 5-HT1 subtype.

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Year:  1986        PMID： 3005002     DOI： 10.1016/0014-2999(86)90544-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  16 in total

Review 1.  The recombinant 5-HT1A receptor: G protein coupling and signalling pathways.

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Review 2.  The 5-HT1A receptor: an overview of recent advances.

Authors:  S el Mestikawy; A Fargin; J R Raymond; H Gozlan; M Hnatowich
Journal:  Neurochem Res       Date:  1991-01       Impact factor: 3.996

3.  Central serotonin receptors: effector systems, physiological roles and regulation.

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Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

Review 4.  The serotonin1A receptor: a representative member of the serotonin receptor family.

Authors:  Thomas J Pucadyil; Shanti Kalipatnapu; Amitabha Chattopadhyay
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046

5.  The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

Authors:  D Julius; K N Huang; T J Livelli; R Axel; T M Jessell
Journal:  Proc Natl Acad Sci U S A       Date:  1990-02       Impact factor: 11.205

6.  The PKC inhibitor, bisindolymaleimide, blocks DOI's attenuation of the effects of 8-OH-DPAT on female rat lordosis behavior.

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Journal:  Behav Brain Res       Date:  2007-01-31       Impact factor: 3.332

7.  The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons.

Authors:  A Dumuis; M Sebben; J Bockaert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-10       Impact factor: 3.000

8.  Activation of 5-HT1A receptors expressed in NIH-3T3 cells induces focus formation and potentiates EGF effect on DNA synthesis.

Authors:  A Varrault; J Bockaert; C Waeber
Journal:  Mol Biol Cell       Date:  1992-09       Impact factor: 4.138

9.  Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons.

Authors:  J Bockaert; A Dumuis; R Bouhelal; M Sebben; R N Cory
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-05       Impact factor: 3.000

10.  Serotonin regulates the phase of the rat suprachiasmatic circadian pacemaker in vitro only during the subjective day.

Authors:  M Medanic; M U Gillette
Journal:  J Physiol       Date:  1992-05       Impact factor: 5.182
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