Sabrina Mörkl , Sonja Lackner , Andreas Meinitzer , Gregor Gorkiewicz , Karl Kashofer , Annamaria Painold , Anna Holl , Sandra Holasek Show Affiliations »
Abstract
INTRODUCTION: Recent research has shown changes of the intestinal flora in anorexia nervosa (AN) patients. Alpha diversity (AD) represents the number of different bacterial species in the gut. Reduced AD and a leaky gut (zonulin) lead to inflammation and changes in nutrient absorption. METHODS: AD was calculated from stool samples of 18 AN patients and 20 normal weight controls (NC) after 16S ribosomal RNA sequencing. Furthermore, Zonulin as an indicator of gut barrier function and inflammation parameters were investigated. RESULTS: AN patients had significantly lower AD compared to NC (number of observed species p=0.042, Chao1 Diversity Index p=0.043). Zonulin was not significantly altered in AN patients compared to NC. There were no significant correlations of serum parameters and AD. DISCUSSION: Regardless of gut permeability, AN patients showed significantly decreased AD compared to NC. Decreased AD can have an additional negative impact on calorie intake in AN. These results contribute to a better understanding of the illness and the development of new therapeutic options. © Georg Thieme Verlag KG Stuttgart · New York.
INTRODUCTION: Recent research has shown changes of the intestinal flora in anorexia nervosa (AN) patients . Alpha diversity (AD ) represents the number of different bacterial species in the gut. Reduced AD and a leaky gut (zonulin ) lead to inflammation and changes in nutrient absorption. METHODS: AD was calculated from stool samples of 18 AN patients and 20 normal weight controls (NC) after 16S ribosomal RNA sequencing. Furthermore, Zonulin as an indicator of gut barrier function and inflammation parameters were investigated. RESULTS: AN patients had significantly lower AD compared to NC (number of observed species p=0.042, Chao1 Diversity Index p=0.043). Zonulin was not significantly altered in AN patients compared to NC. There were no significant correlations of serum parameters and AD . DISCUSSION: Regardless of gut permeability, AN patients showed significantly decreased AD compared to NC. Decreased AD can have an additional negative impact on calorie intake in AN. These results contribute to a better understanding of the illness and the development of new therapeutic options. © Georg Thieme Verlag KG Stuttgart · New York.
Entities: Disease
Gene
Species
Mesh： See more »
Year: 2018
PMID： 30049020 DOI： 10.1055/s-0043-123826
Source DB: PubMed Journal: Fortschr Neurol Psychiatr ISSN： 0720-4299 Impact factor: 0.752