Wanying Shan1,2, Dong Yang1, Huaiming Wang1,3, Liang Xu4, Meng Zhang5, Wenhua Liu6, Wenjie Zi1, Yonggang Hao1, Yunyun Xiong1, Gelin Xu7, Xinfeng Liu1. 1. Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. 2. Department of Neurology, The First People's Hospital of Wujiang, Suzhou, China. 3. Department of Neurology, 89th Hospital of People's Liberation Army, Weifang, China. 4. Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, China. 5. Department of Neurology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China. 6. Department of Neurology, Wuhan No. 1 Hospital, Wuhan, China. 7. Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Chinagelinxu2@126.com.
Abstract
BACKGROUND AND PURPOSE: Clinical trials showed that anesthesia may not influence the functional outcome in stroke patients with endovascular therapy; however, data are lacking in China. Using real-world registry data, our study aims to compare the effects of general anesthesia or conscious sedation on functional outcomes in stroke patients treated with thrombectomy in China. METHODS: Consecutive patients with acute anterior circulation stroke receiving thrombectomy in 21 stroke centers between January 2014 and June 2016 were included in this study. The propensity score analysis with 1: 1 ratio was used to match the baseline variables between patients with general anesthesia and the conscious sedation. The 90-day modified Rankin Scale (mRS), symptomatic intracranial hemorrhage (sICH), and death were compared between groups. RESULTS: Of the 698 patients undergoing endovascular treatment, 138 were treated with general anesthesia and 560 with conscious sedation. After propensity score matching, 114 general anesthesia and 114 conscious sedation patients were matched. The proportions of patients with 90-day mRS 0-2 were not significantly different between general anesthesia and conscious sedation groups (41.2% [47/114] vs. 46.5% [53/114], p = 0.470), nor were the rates of sICH (21.9% [25/114] vs. 12.3% [14/114], p = 0.072) and 90-day mortality (31.6% [36/114] vs. 21.9% [25/114], p = 0.145). CONCLUSION: Anesthesia patterns may have no significant impacts on clinical outcomes in patients with acute anterior circulation occlusion stroke undergoing endovascular treatment in the real-world practice in China.
BACKGROUND AND PURPOSE: Clinical trials showed that anesthesia may not influence the functional outcome in strokepatients with endovascular therapy; however, data are lacking in China. Using real-world registry data, our study aims to compare the effects of general anesthesia or conscious sedation on functional outcomes in strokepatients treated with thrombectomy in China. METHODS: Consecutive patients with acute anterior circulation stroke receiving thrombectomy in 21 stroke centers between January 2014 and June 2016 were included in this study. The propensity score analysis with 1: 1 ratio was used to match the baseline variables between patients with general anesthesia and the conscious sedation. The 90-day modified Rankin Scale (mRS), symptomatic intracranial hemorrhage (sICH), and death were compared between groups. RESULTS: Of the 698 patients undergoing endovascular treatment, 138 were treated with general anesthesia and 560 with conscious sedation. After propensity score matching, 114 general anesthesia and 114 conscious sedation patients were matched. The proportions of patients with 90-day mRS 0-2 were not significantly different between general anesthesia and conscious sedation groups (41.2% [47/114] vs. 46.5% [53/114], p = 0.470), nor were the rates of sICH (21.9% [25/114] vs. 12.3% [14/114], p = 0.072) and 90-day mortality (31.6% [36/114] vs. 21.9% [25/114], p = 0.145). CONCLUSION: Anesthesia patterns may have no significant impacts on clinical outcomes in patients with acute anterior circulation occlusion stroke undergoing endovascular treatment in the real-world practice in China.
Authors: Renato Tosello; Rachel Riera; Giuliano Tosello; Caroline Nb Clezar; Jorge E Amorim; Vladimir Vasconcelos; Benedito B Joao; Ronald Lg Flumignan Journal: Cochrane Database Syst Rev Date: 2022-07-20
Authors: Katharina Feil; Moriz Herzberg; Franziska Dorn; Steffen Tiedt; Clemens Küpper; Dennis C Thunstedt; Ludwig C Hinske; Konstanze Mühlbauer; Sebastian Goss; Thomas Liebig; Marianne Dieterich; Andreas Bayer; Lars Kellert Journal: J Stroke Date: 2021-01-31 Impact factor: 6.967
Authors: Klemens Winder; Michael Knott; Kilian Fröhlich; Gabriela Siedler; Svenja Stoll; Kosmas Macha; Thomas M Kinfe; Arnd Doerfler; Felix Eisenhut; Tobias Engelhorn; Philip Hoelter; Stefan Lang; Iris Muehlen; Manuel Schmidt; Bernd Kallmünzer; Stefan Schwab; Frank Seifert Journal: Neuroradiology Date: 2021-07-10 Impact factor: 2.804