Xiaoyan Pan1,2, Yijing Han3,4, Tiantian Zou3,5, Guiqi Zhu6, Ke Xu3,4, Jina Zheng3,4, Minghua Zheng3,7, Xingbo Cheng1. 1. Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, China. 2. Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 3. Department of Hepatology, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 4. School of the First Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China. 5. School of the Second Clinical Medical Sciences, Wenzhou Medical University, Wenzhou, China. 6. Liver Cancer Institute, Zhongshan Hospital, Fudan University, State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. 7. Institute of Hepatology, Wenzhou Medical University, Wenzhou, China.
Abstract
BACKGROUNDS AND AIMS: Previous studies have investigated that sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis, and fibrosis in NAFLD. The study aims to investigate the risk for NAFLD, especially NAFLD-related significant fibrosis among subjects with sarcopenia. METHODS: We searched electronic databases until 30, September 2017 and reviewed literature extensively. Effect estimates were pooled using random effect models regarding the risk for NAFLD and fixed effect models concerning the risk for significant fibrosis among sarcopenia patients. Sensitivity analysis was performed for the risk of NAFLD. RESULTS: We identified 6 studies. Our results showed that subjects with sarcopenia exhibited an increased risk for NAFLD compared to those without sarcopenia (OR 1.29, 95% CI 1.12-1.49) with heterogeneity among the individual studies (I2 = 61%). And the risk for NAFLD-related significant fibrosis appeared to be more pronounced in sarcopenia patients (OR 1.57, 95% CI 1.29-1.90) with an I2 of 0%. Sensitivity analysis revealed that neither the direction nor the magnitude of the estimated pooled results for NAFLD was obviously affected. Furthermore, the pooled ORs were both close to initial analysis when omitting the study by Hong et al. [Hepatology 2014; 59: 1772-1778] (OR 1.24, 95% CI 1.11-1.39, I2 = 47%) or by Hashimoto et al. [Endocr J 2016; 63: 877-884] (OR 1.33, 95% CI 1.11-1.59, I2 = 67%), which were considered sources of heterogeneity. CONCLUSIONS: Our analysis demonstrated that sarcopenia served not only as a risk factor for the onset of NAFLD but also related to the progression of NAFLD-related significant fibrosis.
BACKGROUNDS AND AIMS: Previous studies have investigated that sarcopenia is associated with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis, and fibrosis in NAFLD. The study aims to investigate the risk for NAFLD, especially NAFLD-related significant fibrosis among subjects with sarcopenia. METHODS: We searched electronic databases until 30, September 2017 and reviewed literature extensively. Effect estimates were pooled using random effect models regarding the risk for NAFLD and fixed effect models concerning the risk for significant fibrosis among sarcopeniapatients. Sensitivity analysis was performed for the risk of NAFLD. RESULTS: We identified 6 studies. Our results showed that subjects with sarcopenia exhibited an increased risk for NAFLD compared to those without sarcopenia (OR 1.29, 95% CI 1.12-1.49) with heterogeneity among the individual studies (I2 = 61%). And the risk for NAFLD-related significant fibrosis appeared to be more pronounced in sarcopeniapatients (OR 1.57, 95% CI 1.29-1.90) with an I2 of 0%. Sensitivity analysis revealed that neither the direction nor the magnitude of the estimated pooled results for NAFLD was obviously affected. Furthermore, the pooled ORs were both close to initial analysis when omitting the study by Hong et al. [Hepatology 2014; 59: 1772-1778] (OR 1.24, 95% CI 1.11-1.39, I2 = 47%) or by Hashimoto et al. [Endocr J 2016; 63: 877-884] (OR 1.33, 95% CI 1.11-1.59, I2 = 67%), which were considered sources of heterogeneity. CONCLUSIONS: Our analysis demonstrated that sarcopenia served not only as a risk factor for the onset of NAFLD but also related to the progression of NAFLD-related significant fibrosis.
Authors: Manu V Chakravarthy; Mohammad S Siddiqui; Mikael F Forsgren; Arun J Sanyal Journal: Front Endocrinol (Lausanne) Date: 2020-12-23 Impact factor: 5.555
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