Heng-Chih Pan1, Kuei-Mei Chou2, Chin-Chan Lee3, Ning-I Yang4, Chiao-Yin Sun5. 1. Division of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan. 2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan. 3. Division of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Chang Gung University College of Medicine, Taoyuan, Taiwan. 4. Chang Gung University College of Medicine, Taoyuan, Taiwan; Division of Cardiology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan. 5. Division of Nephrology, Department of Internal Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan; Chang Gung University College of Medicine, Taoyuan, Taiwan. Electronic address: fish3970@gmail.com.
Abstract
BACKGROUND AND AIMS: Type 2 diabetes is a global health problem that is associated with a wide variety of vascular complications and associated morbidity and mortality. Klotho is an enzyme and transmembrane protein, and increasing evidence suggests that Klotho may contribute to reduced oxidative stress, improved endothelial function, and vasoprotection. To date, the physiological role of Klotho in vascular complications associated with diabetes is unclear. METHODS: We prospectively recruited 252 patients with type 2 diabetes, who visited an outpatient clinic at our hospital between 2009 and 2011. Patients in the top and bottom tertiles of circulating Klotho levels were enrolled for analysis. RESULTS: Of the 168 patients enrolled, 45.8% were male, the mean age was 57.2 years, and the average duration of diabetes was 7.58 years. In multiple regression analysis, a high Klotho level was associated with a reduced risk of developing coronary artery disease and cerebrovascular accidents. Klotho level was also an independent predictor for the development of macroangiopathies within the 7-year study period. CONCLUSIONS: Our results suggest that circulating Klotho level is a predictor of long-term macrovascular outcomes in patients with type 2 diabetes.
BACKGROUND AND AIMS: Type 2 diabetes is a global health problem that is associated with a wide variety of vascular complications and associated morbidity and mortality. Klotho is an enzyme and transmembrane protein, and increasing evidence suggests that Klotho may contribute to reduced oxidative stress, improved endothelial function, and vasoprotection. To date, the physiological role of Klotho in vascular complications associated with diabetes is unclear. METHODS: We prospectively recruited 252 patients with type 2 diabetes, who visited an outpatient clinic at our hospital between 2009 and 2011. Patients in the top and bottom tertiles of circulating Klotho levels were enrolled for analysis. RESULTS: Of the 168 patients enrolled, 45.8% were male, the mean age was 57.2 years, and the average duration of diabetes was 7.58 years. In multiple regression analysis, a high Klotho level was associated with a reduced risk of developing coronary artery disease and cerebrovascular accidents. Klotho level was also an independent predictor for the development of macroangiopathies within the 7-year study period. CONCLUSIONS: Our results suggest that circulating Klotho level is a predictor of long-term macrovascular outcomes in patients with type 2 diabetes.
Authors: Ernesto Martín-Núñez; Atteneri Pérez-Castro; Víctor G Tagua; Carolina Hernández-Carballo; Carla Ferri; Nayra Pérez-Delgado; Sergio Rodríguez-Ramos; Purificación Cerro-López; Ángel López-Castillo; Alejandro Delgado-Molinos; Victoria Castro López-Tarruella; Miguel A Arévalo-Gómez; Ainhoa González-Luis; Alberto Martín-Olivera; Carmen Chaxiraxi Morales-Estévez; Carmen Mora-Fernández; Javier Donate-Correa; Juan F Navarro-González Journal: Sci Rep Date: 2022-05-19 Impact factor: 4.996
Authors: Javier Donate-Correa; Carla M Ferri; Ernesto Martín-Núñez; Nayra Pérez-Delgado; Ainhoa González-Luis; Carmen Mora-Fernández; Juan F Navarro-González Journal: Sci Rep Date: 2021-08-05 Impact factor: 4.379