Ana A Weil1,2, Edward T Ryan1,2,3. 1. Division of Infectious Diseases, Massachusetts General Hospital. 2. Department of Medicine, Harvard Medical School. 3. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA.
Abstract
PURPOSE OF REVIEW: In this review, we will examine updates in cholera epidemiology, advances in our understanding of pathogenesis and protective immunity, and changes to prevention strategies. RECENT FINDINGS: New modeling techniques and molecular epidemiology have led to advancements in our understanding of how Vibrio cholerae has persisted and re-emerged in new areas during the seventh pandemic. Use of next-generation sequencing has shed new light on immune responses to disease and vaccination, and the role of the gut microbiome in cholera. Increased efficacy and availability of vaccines have made long-term goals of global control of cholera more achievable. SUMMARY: Advancements in our understanding of immunity and susceptibility to V. cholerae, in addition to an increased global commitment to disease prevention, have led to optimism for the future of cholera prevention.
PURPOSE OF REVIEW: In this review, we will examine updates in cholera epidemiology, advances in our understanding of pathogenesis and protective immunity, and changes to prevention strategies. RECENT FINDINGS: New modeling techniques and molecular epidemiology have led to advancements in our understanding of how Vibrio cholerae has persisted and re-emerged in new areas during the seventh pandemic. Use of next-generation sequencing has shed new light on immune responses to disease and vaccination, and the role of the gut microbiome in cholera. Increased efficacy and availability of vaccines have made long-term goals of global control of cholera more achievable. SUMMARY: Advancements in our understanding of immunity and susceptibility to V. cholerae, in addition to an increased global commitment to disease prevention, have led to optimism for the future of cholera prevention.
Authors: Kelsey Barrasso; Denise Chac; Meti D Debela; Catherine Geigel; Anjali Steenhaut; Abigail Rivera Seda; Chelsea N Dunmire; Jason B Harris; Regina C Larocque; Firas S Midani; Firdausi Qadri; Jing Yan; Ana A Weil; Wai-Leung Ng Journal: Elife Date: 2022-03-28 Impact factor: 8.713
Authors: Inès Levade; Ashraful I Khan; Fahima Chowdhury; Stephen B Calderwood; Edward T Ryan; Jason B Harris; Regina C LaRocque; Taufiqur R Bhuiyan; Firdausi Qadri; Ana A Weil; B Jesse Shapiro Journal: mSystems Date: 2021-08-24 Impact factor: 6.496