BACKGROUND: At present, the biomarkers which can predict the clinical efficacy of allergen immunotherapy (AIT) are still much debated. IgE levels are often related to allergic severity. Therefore, this study aimed at relating total IgE (tIgE) levels with the efficacy of AIT assessed by symptoms and drug score and skin prick test (SPT) response. METHODS: We evaluated 81 allergic children who had received house-dust mite (HDM) subcutaneous immunotherapy for three years. According to the tIgE levels before treatment, all children were divided into high value, medium value and low value group. Each group according to sIgE/tIgE ratio was divided into subgroups. The efficacy of AIT is assessed by symptoms and drug score. By comparing changes in the grade of SPT in each group, the response of AIT are evaluated. RESULTS: The SPT grade changes to determine efficacy had a high degree of consistency with symptoms and drug score judgment (sensitivity 89.7%, specificity 78.3%, Kappa = 0.670, P < 0.001). Compared to ineffective cases, the effective cases had lower tIgE (P < 0.001) and higher ratio of sIgE/tIgE (P < 0.001). The grades of SPT declined the most in the low value group (low value group vs. medium value group, P < 0.05; low value group vs. high value group, P < 0.001; medium value group vs. high value group, P < 0.05). CONCLUSIONS: The SPT grade change can be used for efficacy evaluation. Children with lower level of tIgE and higher ratio of sIgE/tIgE that obtain a more satisfactory effect.
BACKGROUND: At present, the biomarkers which can predict the clinical efficacy of allergen immunotherapy (AIT) are still much debated. IgE levels are often related to allergic severity. Therefore, this study aimed at relating total IgE (tIgE) levels with the efficacy of AIT assessed by symptoms and drug score and skin prick test (SPT) response. METHODS: We evaluated 81 allergicchildren who had received house-dust mite (HDM) subcutaneous immunotherapy for three years. According to the tIgE levels before treatment, all children were divided into high value, medium value and low value group. Each group according to sIgE/tIgE ratio was divided into subgroups. The efficacy of AIT is assessed by symptoms and drug score. By comparing changes in the grade of SPT in each group, the response of AIT are evaluated. RESULTS: The SPT grade changes to determine efficacy had a high degree of consistency with symptoms and drug score judgment (sensitivity 89.7%, specificity 78.3%, Kappa = 0.670, P < 0.001). Compared to ineffective cases, the effective cases had lower tIgE (P < 0.001) and higher ratio of sIgE/tIgE (P < 0.001). The grades of SPT declined the most in the low value group (low value group vs. medium value group, P < 0.05; low value group vs. high value group, P < 0.001; medium value group vs. high value group, P < 0.05). CONCLUSIONS: The SPT grade change can be used for efficacy evaluation. Children with lower level of tIgE and higher ratio of sIgE/tIgE that obtain a more satisfactory effect.
Entities:
Keywords:
Allergen immunotherapy; Asthma; Efficacy; Skin prick test; Total IgE
Authors: Moisés A Calderón; Thomas B Casale; Alkis Togias; Jean Bousquet; Stephen R Durham; Pascal Demoly Journal: J Allergy Clin Immunol Date: 2010-10-20 Impact factor: 10.793
Authors: Enrico Compalati; Martin Penagos; Francesco Tarantini; Giovanni Passalacqua; Giorgio Walter Canonica Journal: Ann Allergy Asthma Immunol Date: 2009-01 Impact factor: 6.347
Authors: Dan Zeng; Weiguo Li; Juan Zhou; Xiang Wen; Shiyi Chen; Xiaohong Xie; Na Zang; Yu Deng; Luo Ren; Syed A A Rizvi; Yasuo Shimizu; Chan Sun Park; Nikolai Khaltaev; Enmei Liu Journal: Ann Transl Med Date: 2020-11