Hadir M Maher1,2, Nourah Z Alzoman1, Shereen M Shehata1. 1. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11495, P.O. Box 22452, Saudi Arabia. 2. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, University of Alexandria, El-Messalah, Alexandria 21521, Egypt.
Abstract
AIM: The growing interest of cancerous patients in using vitamins, while on imatinib (IMA) therapy, increased the risk of their pharmacokinetic interactions. METHODOLOGY: Ultra-performance LC-MS/MS method was developed and validated for the determination of IMA following oral administration of selected vitamin preparations (vitamin A, E, D3 and C) in rat plasma using a hybrid sample preparation technique of protein precipitation followed by SPE. RESULTS: The method showed good linear response for IMA over the concentration range 1-500 ng/ml. Co-administered vitamin preparations could affect IMA pharmacokinetic profiling through either an increase (vitamin A and E) or a decrease (vitamin C) in IMA bioavailability. Vitamin D3 produced no significant effect on IMA bioavailability. CONCLUSION: Particular concern should be paid when vitamin preparations are administered with IMA.
AIM: The growing interest of cancerouspatients in using vitamins, while on imatinib (IMA) therapy, increased the risk of their pharmacokinetic interactions. METHODOLOGY: Ultra-performance LC-MS/MS method was developed and validated for the determination of IMA following oral administration of selected vitamin preparations (vitamin A, E, D3 and C) in rat plasma using a hybrid sample preparation technique of protein precipitation followed by SPE. RESULTS: The method showed good linear response for IMA over the concentration range 1-500 ng/ml. Co-administered vitamin preparations could affect IMA pharmacokinetic profiling through either an increase (vitamin A and E) or a decrease (vitamin C) in IMA bioavailability. Vitamin D3 produced no significant effect on IMA bioavailability. CONCLUSION: Particular concern should be paid when vitamin preparations are administered with IMA.
Entities:
Keywords:
UPLC–MS/MS; imatinib; pharmacokinetic interaction; rat plasma; vitamin preparations
Authors: Hadir M Maher; Aliyah Almomen; Nourah Z Alzoman; Shereen M Shehata; Amal Al-Subaie Journal: Biomed Res Int Date: 2019-11-28 Impact factor: 3.411