Lawrence Williams1, Lyubov Tmanova1, Wojciech K Mydlarz2,3, Brandi Page4, Jeremy D Richmon5, Harry Quon4, Nicole C Schmitt2,3. 1. 1 Department of Otolaryngology - Head and Neck Surgery, Walter Reed National Military Medical Center, Bethesda, MD, USA. 2. 2 Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, USA. 3. 3 Head and Neck Surgery Branch, National Institute of Deafness and Communication Disorders, National Institutes of Health, Bethesda, MD, USA. 4. 4 Department of Radiation Oncology and Molecular Sciences, Johns Hopkins University, Baltimore, MD, USA. 5. 5 Department of Otolaryngology - Head and Neck Surgery, Massachusetts Eye and Ear Infirmary and Harvard Medical School, Boston, MA, USA.
Abstract
INTRODUCTION: Radiation-associated soft tissue sarcomas of the neck (RASN) constitute a rare and aggressive tumor type. METHODS: A retrospective chart review at the authors' institution revealed 3 patients with RASN. A systematic review of the literature was also conducted using MEDLINE, Ovid, the Cochrane Library, and Embase. RESULTS: Patients within the authors' institutional chart review presented from 6 to 26 years after neck radiation with neck masses. All patients underwent surgical resection with clear margins, and adjuvant radiation was offered when feasible. Patients had no evidence of disease at most recent follow-up. A total of 867 articles were screened for systematic review, revealing 9 articles detailing outcomes of RASN. Studies were small and heterogeneous, precluding pooled data. The importance of complete surgical extirpation was noted. CONCLUSIONS: Complete surgical resection appears to be the mainstay of therapy, but there are limited data on management and outcomes of patients with RASN.
INTRODUCTION: Radiation-associated soft tissue sarcomas of the neck (RASN) constitute a rare and aggressive tumor type. METHODS: A retrospective chart review at the authors' institution revealed 3 patients with RASN. A systematic review of the literature was also conducted using MEDLINE, Ovid, the Cochrane Library, and Embase. RESULTS:Patients within the authors' institutional chart review presented from 6 to 26 years after neck radiation with neck masses. All patients underwent surgical resection with clear margins, and adjuvant radiation was offered when feasible. Patients had no evidence of disease at most recent follow-up. A total of 867 articles were screened for systematic review, revealing 9 articles detailing outcomes of RASN. Studies were small and heterogeneous, precluding pooled data. The importance of complete surgical extirpation was noted. CONCLUSIONS: Complete surgical resection appears to be the mainstay of therapy, but there are limited data on management and outcomes of patients with RASN.
Entities:
Keywords:
head and neck sarcoma; pleomorphic sarcoma; radiation; radiation-induced sarcoma; soft tissue sarcoma
Authors: Andrés Coca-Pelaz; Antti A Mäkitie; Primož Strojan; June Corry; Avraham Eisbruch; Jonathan J Beitler; Sandra Nuyts; Robert Smee; Johannes A Langendijk; William M Mendenhall; Cesare Piazza; Alessandra Rinaldo; Alfio Ferlito Journal: Adv Ther Date: 2020-11-13 Impact factor: 3.845