Itsuko Miyazawa1, Takayoshi Ohkubo2,3, Sayaka Kadowaki2, Akira Fujiyoshi2, Takashi Hisamatsu2,4, Aya Kadota2,5, Hisatomi Arima2,6, Matthew Budoff7, Kiyoshi Murata8, Katsuyuki Miura2,5, Hiroshi Maegawa1, Hirotsugu Ueshima2,5. 1. Department of Medicine, Shiga University of Medical Science. 2. Department of Public Health, Shiga University of Medical Science. 3. Department of Hygiene and Public Health, Teikyo University School of Medicine. 4. Department of Environmental Medicine and Public Health, Faculty of Medicine, Shimane University. 5. Center for Epidemiologic Research in Asia, Shiga University of Medical Science. 6. Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University. 7. Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles. 8. Department of Radiology, Shiga University of Medical Science.
Abstract
BACKGROUND: Pericardial fat volume (PFV), defined as the volume of ectopic fat in and around the heart, is associated with the atherosclerotic process in coronary arteries. The magnitude of change in PFV over time and the factors affecting this change in a general population, however, have not been investigated. Methods and Results: Cardiac computed tomography (CT) was carried out at baseline and at follow-up in 623 Japanese men aged 40-79 years without a history of cardiovascular disease who were selected randomly in Kusatsu (Shiga, Japan). PFV was measured on cardiac CT in a qualified laboratory. Age, heart rate, triglycerides, and obesity measurements (weight, body mass index, and waist circumference) were significantly and positively associated with PFV at baseline. Over an average interval of 4.7 years, median PFV increased significantly from 64.1 cm3 (IQR, 47.2-90.0 cm3) to 73.6 cm3 (IQR, 53.3-98.1 cm3; P<0.001). Current smoking and heart rate were significantly and independently associated with changes in PFV (B=3.336, P<0.001 and B=6.409, P=0.003, respectively). CONCLUSIONS: PFV increased significantly over time in a population-based observational study of Japanese men. PFV change was significantly and independently associated with smoking status and heart rate, suggesting that quitting smoking might help reduce PFV, which could be expected to decrease the risk of coronary artery disease.
BACKGROUND: Pericardial fat volume (PFV), defined as the volume of ectopic fat in and around the heart, is associated with the atherosclerotic process in coronary arteries. The magnitude of change in PFV over time and the factors affecting this change in a general population, however, have not been investigated. Methods and Results: Cardiac computed tomography (CT) was carried out at baseline and at follow-up in 623 Japanese men aged 40-79 years without a history of cardiovascular disease who were selected randomly in Kusatsu (Shiga, Japan). PFV was measured on cardiac CT in a qualified laboratory. Age, heart rate, triglycerides, and obesity measurements (weight, body mass index, and waist circumference) were significantly and positively associated with PFV at baseline. Over an average interval of 4.7 years, median PFV increased significantly from 64.1 cm3 (IQR, 47.2-90.0 cm3) to 73.6 cm3 (IQR, 53.3-98.1 cm3; P<0.001). Current smoking and heart rate were significantly and independently associated with changes in PFV (B=3.336, P<0.001 and B=6.409, P=0.003, respectively). CONCLUSIONS:PFV increased significantly over time in a population-based observational study of Japanese men. PFV change was significantly and independently associated with smoking status and heart rate, suggesting that quitting smoking might help reduce PFV, which could be expected to decrease the risk of coronary artery disease.
Entities:
Keywords:
General population; Longitudinal change; Pericardial fat; Smoking
Authors: Nitesh Nerlekar; Udit Thakur; Andrew Lin; Ji Quan Samuel Koh; Elizabeth Potter; David Liu; Rahul G Muthalaly; Hashrul N Rashid; James D Cameron; Damini Dey; Dennis T L Wong Journal: Sci Rep Date: 2020-04-28 Impact factor: 4.379