Literature DB >> 30047331

Ketoacidosis Due to Empagliflozin, a Paradigm Shift: Case Report and Review of Literature.

Carlos Hernandez-Quiles1, Nieves Ramirez-Duque1, Domingo Acosta-Delgado2.   

Abstract

INTRODUCTION: Sodium-glucose cotransporter 2(SGLT2)-inhibitors are new antihyperglycemic agents that have shown a reduction in cardiovascular events in type 2 diabetes mellitus. Recent warnings have been developed about an increased risk of euglycemic and moderate hyperglycemic diabetic ketoacidosis with the use of SGLT2 inhibitors, but its real incidence is not available yet. CASE REPORT: We present a case of DKA with moderate hyperglycemia in a patient treated with metformin and empagliflozin.
CONCLUSION: DKA in patients treated with SGLT2 inhibitors can be presented as euglycemic and moderated hyperglycemia. This special presentation poses a physician's challenge. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  SGLT2 inhibitors; Sodium glucose cotransporter 2; diabetes mellitus; diabetic ketoacidosis; empagliflozin; euglycemia.

Year:  2019        PMID: 30047331     DOI: 10.2174/1573399814666180726114044

Source DB:  PubMed          Journal:  Curr Diabetes Rev        ISSN: 1573-3998


  2 in total

1.  Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine.

Authors:  Jill A Kanaley; Sheri R Colberg; Matthew H Corcoran; Steven K Malin; Nancy R Rodriguez; Carlos J Crespo; John P Kirwan; Juleen R Zierath
Journal:  Med Sci Sports Exerc       Date:  2022-02-01       Impact factor: 5.411

2.  SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.

Authors:  Heeyoung Chae; Robert Augustin; Eva Gatineau; Eric Mayoux; Mohammed Bensellam; Nancy Antoine; Firas Khattab; Bao-Khanh Lai; Davide Brusa; Birgit Stierstorfer; Holger Klein; Bilal Singh; Lucie Ruiz; Michael Pieper; Michael Mark; Pedro L Herrera; Fiona M Gribble; Frank Reimann; Anne Wojtusciszyn; Christophe Broca; Nano Rita; Lorenzo Piemonti; Patrick Gilon
Journal:  Mol Metab       Date:  2020-09-05       Impact factor: 7.422

  2 in total

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