Literature DB >> 30047065

Clear Cell Odontogenic Carcinoma: Occurrence of EWSR1-CREB1 as Alternative Fusion Gene to EWSR1-ATF1.

Rob Vogels1,2, Daniel Baumhoer3, Joost van Gorp4, Astrid Eijkelenboom1, Marian Verdijk1, Patricia van Cleef1, Elisabeth Bloemena1,5, Pieter J Slootweg1, Bjorn Lohman6, Maria Debiec-Rychter7, Uta Flucke8.   

Abstract

Clear cell odontogenic carcinoma (CCOC) is a rare, low-grade malignant epithelial neoplasm, occurring in the jawbones, mainly affecting the mandible of elderly patients. In addition to hyalinizing clear cell carcinoma of the salivary gland, it is one of the epithelial neoplasms known to harbor an EWSR1-ATF1 fusion. Therefore, a link between these tumors seems plausible. We describe six cases of CCOC showing EWSR1 rearrangements, with two cases being positive for the ATF1 partner gene using FISH analysis. In one case, an EWSR1-CREB1 fusion was identified using RT-PCR, which we report for the first time in this tumor type. The other three cases investigated by FISH were negative for ATF1, CREB1 and CREB3L2. In conclusion, our data show that EWSR1-CREB1 is an alternative fusion gene to EWSR1-ATF1 in CCOC.

Entities:  

Keywords:  Clear cell odontogenic carcinoma; EWSR1-ATF1; EWSR1-CREB1; FISH; Gene fusion; RT-PCR

Year:  2018        PMID： 30047065      PMCID： PMC6514205          DOI： 10.1007/s12105-018-0953-z

Source DB:  PubMed          Journal:  Head Neck Pathol        ISSN： 1936-055X


  10 in total

Review 1.  Development of head and neck pathology in Europe.

Authors:  Henrik Hellquist; Abbas Agaimy; Göran Stenman; Alessandro Franchi; Alfons Nadal; Alena Skalova; Ilmo Leivo; Nina Zidar; Roderick H W Simpson; Pieter J Slootweg; Juan C Hernandez-Prera; Alfio Ferlito
Journal:  Virchows Arch       Date:  2022-01-14       Impact factor: 4.064

Review 2.  Rare clear cell odontogenic carcinoma associated with impacted tooth in a young patient: case report and literature review.

Authors:  Erasmo Bernardo Marinho; Ana Paula Negreiros Nunes Alves; Francisco Januário Farias Pereira-Filho; Antonio Ernando Carlos Ferreira-Junior; Mário Rogério Lima Mota; Fabricio Bitu Sousa
Journal:  Oral Maxillofac Surg       Date:  2021-09-20

Review 3.  Clear Cell Odontogenic Carcinoma a Systematic Review.

Authors:  Alberto Jose Peraza Labrador; Nestor Ricardo Gonzalez Marin; Luciano Hermios Matos Valdez; Martinez P Valentina; Katman Bear Toledo Sanchez; Karem Annelise Rodriguez Ibazetta; Basterrechea Johan; Abad Villacrez Cesar; John M Wright
Journal:  Head Neck Pathol       Date:  2021-10-07

4.  SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets.

Authors:  Sandra N Freiberger; Muriel Brada; Christine Fritz; Sylvia Höller; Alexander Vogetseder; Milo Horcic; Michel Bihl; Michal Michal; Martin Lanzer; Martin Wartenberg; Urs Borner; Peter K Bode; Martina A Broglie; Tamara Rordorf; Grégoire B Morand; Niels J Rupp
Journal:  Neoplasia       Date:  2021-04-18       Impact factor: 5.715

5.  Clinicopathological and molecular study of 10 salivary gland clear cell carcinomas, with emphasis on rare cases with high grade transformation and occurring in uncommon sites.

Authors:  Lanlan Xuan; Suxia Wang; Jianguo Wei; Jianwei Yuan; Honggang Liu
Journal:  Diagn Pathol       Date:  2022-01-30       Impact factor: 2.644

6.  Comprehensive genomic profiling of EWSR1/FUS::CREB translocation-associated tumors uncovers prognostically significant recurrent genetic alterations and methylation-transcriptional correlates.

Authors:  Josephine K Dermawan; Fabio Vanoli; Laurie Herviou; Yun-Shao Sung; Lei Zhang; Samuel Singer; William D Tap; Ryma Benayed; Tejus A Bale; Jamal K Benhamida; Brendan C Dickson; Cristina R Antonescu
Journal:  Mod Pathol       Date:  2022-03-28       Impact factor: 8.209

7.  Clear Cell Odontogenic Carcinoma Harboring the EWSR1-ATF1 Fusion Gene: Report of a Rare Case.

Authors:  Thalita Santana; Felipe Ledo de Andrade; Maria Carolina de Sousa Melo; Glauber Bareia Liberato da Rocha; Marília Trierveiler
Journal:  Head Neck Pathol       Date:  2019-11-28

8.  Clear Cell Odontogenic Carcinoma: First Report of Novel EWSR1-CREM Fusion Gene in Case of Long-Term Misdiagnosis.

Authors:  Omar Breik; James Higginson; Abdulla K Al-Ajami; Abubakar Mohamed; Tim Martin; Rasoul Amel-Kashipaz
Journal:  Head Neck Pathol       Date:  2021-02-22

Review 9.  The spectrum of rare central nervous system (CNS) tumors with EWSR1-non-ETS fusions: experience from three pediatric institutions with review of the literature.

Authors:  Oscar Lopez-Nunez; Barbara Cafferata; Mariarita Santi; Sarangarajan Ranganathan; Thomas M Pearce; Scott M Kulich; Kelly M Bailey; Alberto Broniscer; Sabrina Rossi; Angelica Zin; MacLean P Nasrallah; Marilyn M Li; Yiming Zhong; Evelina Miele; Rita Alaggio; Lea F Surrey
Journal:  Brain Pathol       Date:  2020-11-06       Impact factor: 6.508

10.  Malignant Odontogenic Tumours: A Systematic Review of Cases Reported in Literature.

Authors:  Constanza Marin; Manas Dave; Keith D Hunter
Journal:  Front Oral Health       Date:  2021-11-19
  10 in total

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