Literature DB >> 30046987

The number of CD34+CD133+ hematopoietic stem cells residing in umbilical cord blood (UCB) units is not correlated with the numbers of total nucleated cells and CD34+ cells: a possible new indicator for quality evaluation of UCB units.

Yoshikazu Matsuoka1, Fumiaki Nakamura2, Kazuo Hatanaka3, Tatsuya Fujioka1, Satoshi Otani4, Takafumi Kimura4, Yoshihiro Fujimura4, Hiroaki Asano5, Yoshiaki Sonoda6.   

Abstract

Umbilical cord blood transplantation (UCBT) is often associated with delayed neutrophil and platelet recovery. Engraftment failure is another major obstacle. Several factors influence these serious complications, including the numbers of total nucleated cells (TNCs) and CD34+ cells which have been used as reliable factors for selecting UCB units for transplantation. However, whether both factors are reliable indices of the hematopoietic stem cell (HSC) activity of UCB units remains unknown. To evaluate the quality of UCB units, we quantified the actual number of transplantable CD34+CD133+ HSCs (tHSCs) residing in UCB units. The number of tHSCs was not correlated with the numbers of TNCs or CD34+ cells. These results strongly suggest that neither factor reflects the numbers of tHSCs residing in UCB units. To validate the significance of the number of tHSCs, further analysis is required to determine whether the number of tHSCs residing in UCB units is useful as a new indicator for the quality assessment of UCB units.

Entities:  

Keywords:  CD34+CD133+ HSCs; Quality assurance; UCB units; UCBT

Mesh：

Substances：

Year:  2018        PMID： 30046987     DOI： 10.1007/s12185-018-2502-7

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  31 in total

1.  In vivo dynamics of human cord blood-derived CD34(-) SCID-repopulating cells using intra-bone marrow injection.

Authors:  T Kimura; Y Matsuoka; M Murakami; T Kimura; M Takahashi; T Nakamoto; K Yasuda; K Matsui; K Kobayashi; S Imai; H Asano; R Nakatsuka; Y Uemura; Y Sasaki; Y Sonoda
Journal:  Leukemia       Date:  2009-10-01       Impact factor: 11.528

2.  GPI-80 expression highly purifies human cord blood-derived primitive CD34-negative hematopoietic stem cells.

Authors:  Yoshikazu Matsuoka; Keisuke Sumide; Hiroshi Kawamura; Ryusuke Nakatsuka; Tatsuya Fujioka; Yoshiaki Sonoda
Journal:  Blood       Date:  2016-09-13       Impact factor: 22.113

Review 3.  CD34: structure, biology, and clinical utility.

Authors:  D S Krause; M J Fackler; C I Civin; W S May
Journal:  Blood       Date:  1996-01-01       Impact factor: 22.113

4.  NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

Authors:  Mamoru Ito; Hidefumi Hiramatsu; Kimio Kobayashi; Kazutomo Suzue; Mariko Kawahata; Kyoji Hioki; Yoshito Ueyama; Yoshio Koyanagi; Kazuo Sugamura; Kohichiro Tsuji; Toshio Heike; Tatsutoshi Nakahata
Journal:  Blood       Date:  2002-11-01       Impact factor: 22.113

5.  Transplants of umbilical-cord blood or bone marrow from unrelated donors in adults with acute leukemia.

Authors:  Vanderson Rocha; Myriam Labopin; Guillermo Sanz; William Arcese; Rainer Schwerdtfeger; Alberto Bosi; Niels Jacobsen; Tapani Ruutu; Marcos de Lima; Jürgen Finke; Francesco Frassoni; Eliane Gluckman
Journal:  N Engl J Med       Date:  2004-11-25       Impact factor: 91.245

6.  Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospective analysis.

Authors:  Mary Eapen; Vanderson Rocha; Guillermo Sanz; Andromachi Scaradavou; Mei-Jie Zhang; William Arcese; Anne Sirvent; Richard E Champlin; Nelson Chao; Adrian P Gee; Luis Isola; Mary J Laughlin; David I Marks; Samir Nabhan; Annalisa Ruggeri; Robert Soiffer; Mary M Horowitz; Eliane Gluckman; John E Wagner
Journal:  Lancet Oncol       Date:  2010-07       Impact factor: 41.316

7.  Transplantation-related mortality, graft failure, and survival after reduced-toxicity conditioning and allogeneic hematopoietic stem cell transplantation in 100 consecutive pediatric recipients.

Authors:  Prakash Satwani; Zhezhen Jin; Deirdre Duffy; Erin Morris; Monica Bhatia; James H Garvin; Diane George; Mary Brigid Bradley; Lauren Harrison; Kristen Petrillo; Joseph Schwartz; Sandra Foley; Ria Hawks; Lee Ann Baxter-Lowe; Mitchell S Cairo
Journal:  Biol Blood Marrow Transplant       Date:  2012-12-16       Impact factor: 5.742

Review 8.  Hematopoietic stem cell transplantation donor sources in the 21st century: choosing the ideal donor when a perfect match does not exist.

Authors:  Natasha Kekre; Joseph H Antin
Journal:  Blood       Date:  2014-06-09       Impact factor: 22.113

Review 9.  Cord Blood Transplantation: Can We Make it Better?

Authors:  Leland Metheny; Paolo Caimi; Marcos de Lima
Journal:  Front Oncol       Date:  2013-09-17       Impact factor: 6.244

10.  CD133 is a positive marker for a distinct class of primitive human cord blood-derived CD34-negative hematopoietic stem cells.

Authors:  M Takahashi; Y Matsuoka; K Sumide; R Nakatsuka; T Fujioka; H Kohno; Y Sasaki; K Matsui; H Asano; K Kaneko; Y Sonoda
Journal:  Leukemia       Date:  2013-11-05       Impact factor: 11.528
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  2 in total

1.  Similarities Between Stem Cell Niches in Glioblastoma and Bone Marrow: Rays of Hope for Novel Treatment Strategies.

Authors:  Vashendriya V V Hira; Barbara Breznik; Miloš Vittori; Annique Loncq de Jong; Jernej Mlakar; Roelof-Jan Oostra; Mohammed Khurshed; Remco J Molenaar; Tamara Lah; Cornelis J F Van Noorden
Journal:  J Histochem Cytochem       Date:  2019-09-30       Impact factor: 2.479

2.  Development of LT-HSC-Reconstituted Non-Irradiated NBSGW Mice for the Study of Human Hematopoiesis In Vivo.

Authors:  George Adigbli; Peng Hua; Masateru Uchiyama; Irene Roberts; Joanna Hester; Suzanne M Watt; Fadi Issa
Journal:  Front Immunol       Date:  2021-03-25       Impact factor: 7.561
  2 in total

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