Halloysite nanotubes in analytical sciences and in drug delivery: A review.

Halloysite (HNT) is a natural inorganic mineral that has many applications in manufacturing. This review (with 192 references) covers (a) the chemical properties of halloysites, (b) the effects of alkali and acid etching on the loading capacity and the release behavior of halloysites, (c) the use of halloysite nanotubes in analytical sciences and drug delivery, and (d) recent trends in the preparation of magnetic HNTs. Synthetic methods such as co-precipitation, thermal decomposition, and solvothermal method are discussed, with emphasis on optimal magnetization. In the analytical field, recent advancements are summarized in terms of applications of HNT-nanocomposites for extraction and detection of heavy metal ions, dyes, organic pollutants, and biomolecules. The review also covers methods for synthesizing molecularly imprinted polymer-modified HNTs and magnetic HNTs. With respect to drug delivery, the toxicity, techniques for drug loading and the various classes of drug-halloysite nanocomposites are discussed. This review gives a general insight on the utilization of HNT in analytical determination and drug delivery systems which may be useful for researchers to generate new ideas. Graphical abstract Schematic presentation of the structure of halloysite nanotubes, selected examples of modifications and functionalization, and represetative field of applications.