Justin C Strickland1, Katherine R Marks2, Joshua S Beckmann1, Joshua A Lile1,2,3, Craig R Rush1,2,3, William W Stoops4,5,6,7. 1. Department of Psychology, University of Kentucky College of Arts and Sciences, 171 Funkhouser Drive, Lexington, KY, 40506-0044, USA. 2. Department of Behavioral Science, University of Kentucky Chandler Medical Center, 1100 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington, KY, 40536-0086, USA. 3. Department of Psychiatry, University of Kentucky College of Medicine, 3470 Blazer Parkway, Lexington, KY, 40509-1810, USA. 4. Department of Psychology, University of Kentucky College of Arts and Sciences, 171 Funkhouser Drive, Lexington, KY, 40506-0044, USA. william.stoops@uky.edu. 5. Department of Behavioral Science, University of Kentucky Chandler Medical Center, 1100 Veterans Drive, Medical Behavioral Science Building Room 140, Lexington, KY, 40536-0086, USA. william.stoops@uky.edu. 6. Department of Psychiatry, University of Kentucky College of Medicine, 3470 Blazer Parkway, Lexington, KY, 40509-1810, USA. william.stoops@uky.edu. 7. Center on Drug and Alcohol Research, University of Kentucky College of Medicine, 845 Angliana Ave, Lexington, KY, 40508, USA. william.stoops@uky.edu.
Abstract
RATIONALE: Theoretical accounts highlight the importance of drug-related cues for the development and persistence of drug-taking behavior. Few studies have evaluated the ability of spatially contiguous drug cues to bias decisions between two concurrently presented non-drug reinforcers. OBJECTIVE: Evaluate the contribution of spatially contiguous cocaine cues to choice between two concurrently presented monetary reinforcers METHODS: Participants with cocaine use disorder completed a cued concurrent choice task. Two cues (one cocaine and one control image) were presented side-by-side followed by concurrent monetary offers below each image. Concurrent choice was measured for cocaine-side advantageous, equal, and disadvantageous concurrent monetary offers. The primary dependent measure was bias for selecting cocaine-cued monetary reinforcers. Three experiments tested selectivity of cocaine-cued bias in individuals with a cocaine use history (Experiment 1), replication when including additional control trials (Experiment 2), and a potential attentional mechanism evaluated using eye-tracking technology (Experiment 3). RESULTS: Significant and robust cocaine-cued bias at equal monetary value was observed in three experiments (mean percent choice = 65-77%) and higher Drug Abuse Screening Test (DAST) scores were associated with greater cocaine-choice bias. These experiments demonstrated that cocaine-cued bias was (1) selective to individuals with a cocaine use history, (2) specific to trials involving a cocaine cue, and (3) partially associated with attentional bias. CONCLUSIONS: These experiments provide evidence that drug-related cues can influence choice and potentially promote maladaptive decision making during concurrent choice events. Future research evaluating prospective associations of drug-cued bias with drug-associated behaviors will help reveal the clinical relevance for substance use disorder.
RATIONALE: Theoretical accounts highlight the importance of drug-related cues for the development and persistence of drug-taking behavior. Few studies have evaluated the ability of spatially contiguous drug cues to bias decisions between two concurrently presented non-drug reinforcers. OBJECTIVE: Evaluate the contribution of spatially contiguous cocaine cues to choice between two concurrently presented monetary reinforcers METHODS:Participants with cocaine use disorder completed a cued concurrent choice task. Two cues (one cocaine and one control image) were presented side-by-side followed by concurrent monetary offers below each image. Concurrent choice was measured for cocaine-side advantageous, equal, and disadvantageous concurrent monetary offers. The primary dependent measure was bias for selecting cocaine-cued monetary reinforcers. Three experiments tested selectivity of cocaine-cued bias in individuals with a cocaine use history (Experiment 1), replication when including additional control trials (Experiment 2), and a potential attentional mechanism evaluated using eye-tracking technology (Experiment 3). RESULTS: Significant and robust cocaine-cued bias at equal monetary value was observed in three experiments (mean percent choice = 65-77%) and higher Drug Abuse Screening Test (DAST) scores were associated with greater cocaine-choice bias. These experiments demonstrated that cocaine-cued bias was (1) selective to individuals with a cocaine use history, (2) specific to trials involving a cocaine cue, and (3) partially associated with attentional bias. CONCLUSIONS: These experiments provide evidence that drug-related cues can influence choice and potentially promote maladaptive decision making during concurrent choice events. Future research evaluating prospective associations of drug-cued bias with drug-associated behaviors will help reveal the clinical relevance for substance use disorder.
Authors: Scott J Moeller; Thomas Maloney; Muhammad A Parvaz; Jonathan P Dunning; Nelly Alia-Klein; Patricia A Woicik; Greg Hajcak; Frank Telang; Gene-Jack Wang; Nora D Volkow; Rita Z Goldstein Journal: Biol Psychiatry Date: 2009-04-09 Impact factor: 13.382
Authors: Aaron P Smith; Rebecca S Hofford; Thomas R Zentall; Joshua S Beckmann Journal: Psychopharmacology (Berl) Date: 2018-02-18 Impact factor: 4.530
Authors: Katherine R Marks; Walter Roberts; William W Stoops; Erika Pike; Mark T Fillmore; Craig R Rush Journal: Addiction Date: 2014-07-02 Impact factor: 6.526
Authors: Matthew W Johnson; Justin C Strickland; Evan S Herrmann; Sean B Dolan; David J Cox; Meredith S Berry Journal: Exp Clin Psychopharmacol Date: 2020-10-01 Impact factor: 3.157