Karsten Wolter 1 , Georges Decker 1 , Daniel Kuetting 1 , Jonel Trebicka 2 , Steffen Manekeller 3 , Carsten Meyer 1 , Hans Schild 1 , Daniel Thomas 1 Show Affiliations »
Abstract
BACKGROUND: Acute portal vein thrombosis is a potentially fatal condition. In symptomatic patients not responding to systemic anticoagulation, interventional procedures have emerged as an alternative to surgery. This study sought to retrospectively evaluate initial results of interventional treatment of acute portal vein thrombosis (aPVT) using a transjugular interventional approach. MATERIALS AND METHODS: Between 2014 and 2016, 11 patients were treated because of aPVT (male: 7; female: 4; mean age: 41.06 years). All patients presented a rapid onset of symptoms without collateralization of portal flow as assessed by a CT scan at the time of admittance. The patients showed thrombotic occlusion of the main portal vein (11/11), the lienal vein (10/11) and the superior mesenteric vein (10/11). Different techniques for recanalization were employed: catheter thromboaspiration (1/9), AngioJet device (7/9), local-lysis-only (1/9) and TIPSS (7/9). Local lysis was administered using a dual (4/9) or single (5/9) catheter technique. The mean follow-up was 24.32 months. RESULTS: In 9 patients transhepatic access was successful. Initially reduction of thrombus load and recanalization were achieved in all 9 cases with residual thrombi in PV (n = 3), SMV (n = 7), and IL (n = 5). In the collective undergoing interventional procedures (n = 9) rethrombosis and continuous abdominal pain were seen in one patient, and thrombus progression after successful recanalization was seen in another. Freedom from symptoms could be achieved in 6 patients. One patient developed peritoneal and pleural effusion, respiratory insufficiency and portosystemic collaterals. Both patients who could not undergo an interventional procedure developed a cavernous transformation of the portal vein. One of them also had continuous intermittent abdominal pain. CONCLUSION: Interventional percutaneous approaches are able to improve patient outcome in patients with aPVT. It appears to be of utmost importance to not only remove/reduce the thrombotic material but to establish sufficient inflow and outflow by TIPS and simultaneous multi-catheter thrombolysis. KEY POINTS: · Pharmacomechanic thrombectomy in combination with local thrombolysis is a feasible approach. · The transjugular transhepatic approach seems to be a safe procedure. · TIPSS and dual catheter lysis may support flow management. CITATION FORMAT: · Wolter K, Decker G, Kuetting D et al. Interventional Treatment of Acute Portal Vein Thrombosis. Fortschr Röntgenstr 2018; 190: 740 - 746. © Georg Thieme Verlag KG Stuttgart · New York.
BACKGROUND: Acute portal vein thrombosis is a potentially fatal condition. In symptomatic patients not responding to systemic anticoagulation, interventional procedures have emerged as an alternative to surgery. This study sought to retrospectively evaluate initial results of interventional treatment of acute portal vein thrombosis (aPVT) using a transjugular interventional approach. MATERIALS AND METHODS: Between 2014 and 2016, 11 patients were treated because of aPVT (male: 7; female: 4; mean age: 41.06 years). All patients presented a rapid onset of symptoms without collateralization of portal flow as assessed by a CT scan at the time of admittance. The patients showed thrombotic occlusion of the main portal vein (11/11), the lienal vein (10/11) and the superior mesenteric vein (10/11). Different techniques for recanalization were employed: catheter thromboaspiration (1/9), AngioJet device (7/9), local-lysis-only (1/9) and TIPSS (7/9). Local lysis was administered using a dual (4/9) or single (5/9) catheter technique. The mean follow-up was 24.32 months. RESULTS: In 9 patients transhepatic access was successful. Initially reduction of thrombus load and recanalization were achieved in all 9 cases with residual thrombi in PV (n = 3), SMV (n = 7), and IL (n = 5). In the collective undergoing interventional procedures (n = 9) rethrombosis and continuous abdominal pain were seen in one patient , and thrombus progression after successful recanalization was seen in another. Freedom from symptoms could be achieved in 6 patients . One patient developed peritoneal and pleural effusion , respiratory insufficiency and portosystemic collaterals. Both patients who could not undergo an interventional procedure developed a cavernous transformation of the portal vein. One of them also had continuous intermittent abdominal pain . CONCLUSION: Interventional percutaneous approaches are able to improve patient outcome in patients with aPVT. It appears to be of utmost importance to not only remove/reduce the thrombotic material but to establish sufficient inflow and outflow by TIPS and simultaneous multi-catheter thrombolysis . KEY POINTS: · Pharmacomechanic thrombectomy in combination with local thrombolysis is a feasible approach. · The transjugular transhepatic approach seems to be a safe procedure. · TIPSS and dual catheter lysis may support flow management. CITATION FORMAT: · Wolter K, Decker G, Kuetting D et al. Interventional Treatment of Acute Portal Vein Thrombosis . Fortschr Röntgenstr 2018; 190: 740 - 746. © Georg Thieme Verlag KG Stuttgart · New York.
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Year: 2018
PMID： 30045398 DOI： 10.1055/a-0631-9265
Source DB: PubMed Journal: Rofo ISSN： 1438-9010