Ahmet Karatas1, Ercan Turkmen2, Emre Erdem3, Harun Dugeroglu4, Yasemin Kaya4. 1. Department of Nephrology, Ordu University Faculty of Medicine, Ordu, Turkey. 2. Nephrology Clinic, Ordu State Hospital, Ordu, Turkey. 3. Samsun Dialysis Clinic, Samsun Dialysis, Samsun, Turkey. 4. Department of Internal Medicine, Ordu University Faculty of Medicine, Ordu, Turkey.
Abstract
AIM: We investigated the relationship of monocyte to high-density lipoprotein cholesterol ratio (MHR) with diabetes mellitus and diabetic nephropathy. METHODS & RESULTS: A total of 220 diabetes mellitus patients and 70 healthy controls were enrolled. There was no difference in an MHR between normoalbuminuric diabetic patients and the healthy controls. The MHR in patients with diabetic nephropathy was significantly higher than that of both the normoalbuminuric diabetic patients and the healthy controls. There was a significant positive correlation between urine albumin to creatinine ratio and the MHR. In multivariate linear regression analysis, the MHR was independently correlated with urine albumin to creatinine ratio. Conclusion: An increased MHR may be a biomarker for diabetic nephropathy.
AIM: We investigated the relationship of monocyte to high-density lipoprotein cholesterol ratio (MHR) with diabetes mellitus and diabetic nephropathy. METHODS & RESULTS: A total of 220 diabetes mellituspatients and 70 healthy controls were enrolled. There was no difference in an MHR between normoalbuminuric diabeticpatients and the healthy controls. The MHR in patients with diabetic nephropathy was significantly higher than that of both the normoalbuminuric diabeticpatients and the healthy controls. There was a significant positive correlation between urine albumin to creatinine ratio and the MHR. In multivariate linear regression analysis, the MHR was independently correlated with urine albumin to creatinine ratio. Conclusion: An increased MHR may be a biomarker for diabetic nephropathy.
Entities:
Keywords:
diabetes mellitus; diabetic nephropathy; inflammation; monocyte count; monocyte to high-density lipoprotein cholesterol ratio; urine albumin to creatinine ratio