Literature DB >> 3004327

The inactivation of herpes simplex virus by some Solanaceae glycoalkaloids.

H V Thorne, G F Clarke, R Skuce.   

Abstract

The infectivity of herpes simplex virus Type I in tissue culture was inhibited by prior incubation with aqueous suspensions of glycoalkaloids in order of activity alpha-chaconine greater than alpha-tomatine greater than alpha-solasonine but not by the corresponding aglycones, solanidine, tomatidine and solasodine. However, inhibition was not only dependent on the presence of a sugar moiety since the glycone alpha-solanine was inactive under the conditions used. The glycones, but not the aglycones, showed cytopathic effects on cellular membranes of Vero cells and erythrocytes; therefore, it is suggested that inactivation of virus results from insertion of the glycones into the viral envelope.

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Year:  1985        PMID： 3004327     DOI： 10.1016/0166-3542(85)90003-8

Source DB:  PubMed          Journal:  Antiviral Res        ISSN： 0166-3542            Impact factor:   5.970


  10 in total

1.  A major QTL and an SSR marker associated with glycoalkaloid content in potato tubers from Solanum tuberosum x S. sparsipilum located on chromosome I.

Authors:  Kirsten Kørup Sørensen; Hanne Grethe Kirk; Kerstin Olsson; Rodrigo Labouriau; Jørgen Christiansen
Journal:  Theor Appl Genet       Date:  2008-03-29       Impact factor: 5.699

2.  A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways.

Authors:  C M Lezama-Dávila; J D McChesney; J K Bastos; M A Miranda; R F Tiossi; J de C da Costa; M V Bentley; S E Gaitan-Puch; A P Isaac-Márquez
Journal:  Antimicrob Agents Chemother       Date:  2016-04-22       Impact factor: 5.191

3.  Synergistic interaction between potato glycoalkaloidsα-solanine andα-chaconine in relation to destabilization of cell membranes: Ecological implications.

Authors:  J G Roddick; A L Rijnenberg; S F Osman
Journal:  J Chem Ecol       Date:  1988-03       Impact factor: 2.626

4.  Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells.

Authors:  Sui-Ting Lee; Pooi-Fong Wong; Shiau-Chuen Cheah; Mohd Rais Mustafa
Journal:  PLoS One       Date:  2011-04-26       Impact factor: 3.240

5.  α-Solanine induces ROS-mediated autophagy through activation of endoplasmic reticulum stress and inhibition of Akt/mTOR pathway.

Authors:  M Hasanain; A Bhattacharjee; P Pandey; R Ashraf; N Singh; S Sharma; A L Vishwakarma; D Datta; K Mitra; J Sarkar
Journal:  Cell Death Dis       Date:  2015-08-27       Impact factor: 8.469

6.  α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167).

Authors:  Ayşe Kübra Karaboğa Arslan; Mükerrem Betül Yerer
Journal:  Nutrients       Date:  2018-05-25       Impact factor: 5.717

Review 7.  Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review.

Authors:  Mendel Friedman; Christina C Tam; Luisa W Cheng; Kirkwood M Land
Journal:  BMC Complement Med Ther       Date:  2020-09-09

8.  Antimicrobial properties of tomato leaves, stems, and fruit and their relationship to chemical composition.

Authors:  Christina C Tam; Kevin Nguyen; Daniel Nguyen; Sabrina Hamada; Okhun Kwon; Irene Kuang; Steven Gong; Sydney Escobar; Max Liu; Jihwan Kim; Tiffany Hou; Justin Tam; Luisa W Cheng; Jong H Kim; Kirkwood M Land; Mendel Friedman
Journal:  BMC Complement Med Ther       Date:  2021-09-13

9.  The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes.

Authors:  Junya Fujimaki; Neo Sayama; Shigenobu Shiotani; Takanori Suzuki; Miki Nonaka; Yasuhito Uezono; Mamoru Oyabu; Yasutomi Kamei; Haruo Nukaya; Keiji Wakabayashi; Akihito Morita; Tomoki Sato; Shinji Miura
Journal:  Nutrients       Date:  2022-02-28       Impact factor: 5.717

10.  The cytotoxic effect of α-tomatine in MCF-7 human adenocarcinoma breast cancer cells depends on its interaction with cholesterol in incubation media and does not involve apoptosis induction.

Authors:  Lenka Sucha; Milos Hroch; Martina Rezacova; Emil Rudolf; Radim Havelek; Ludek Sispera; Jana Cmielova; Renata Kohlerova; Ales Bezrouk; Pavel Tomsik
Journal:  Oncol Rep       Date:  2013-10-02       Impact factor: 3.906
  10 in total

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