K Magnusson1, J Kumm2, A Turkiewicz3, M Englund4. 1. Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden; National Advisory Unit on Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway. Electronic address: karin.magnusson@med.lu.se. 2. Department of Radiology, University of Tartu, Tartu, Estonia. Electronic address: Jaanika.Kumm@kliinikum.ee. 3. Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden. Electronic address: aleksandra.turkiewicz@med.lu.se. 4. Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Orthopaedics, Clinical Epidemiology Unit, Lund, Sweden; Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USA. Electronic address: martin.englund@med.lu.se.
Abstract
AIM: To study the development of early knee osteoarthritis (OA) in subjects with and without risk factors for knee OA. METHODS: We studied 340 subjects from the Osteoarthritis Initiative (OAI), aged 45-55 years (51% women), free of radiographic knee OA at baseline (n = 294 with and n = 46 without knee pain and other OA risk factors). At baseline, 24, 48, 72 and 96 months we compared the two groups for prevalence and overlap of knee OA as defined by magnetic resonance imaging (MRI-based OA), x-rays (Kellgren-Lawrence grade [KLG] ≥ 1), and pain, using a logistic mixed model. We studied the group differences (%) over time by subtracting the OA prevalence of those without risk factors from the group with risk factors. RESULTS: The group with OA risk factors had higher proportions of MRI-based OA than the group without OA risk factors at all visits, but the difference diminished at 72 months (72 months difference = 11.9%, 95% confidence intervals [CI] = -2.3-26.1). Further, at 72 months, the presence of KLG ≥ 1 were similar in the two groups (-3.5%, 95% CI = -15.2-8.2). The proportion fulfilling all three OA definitions was 1.7% at 24 months and 4.8% at 72 months of those with OA risk factors and 0% and 2.2%, respectively, in those without. CONCLUSION: Structural changes of the knee are common irrespective of the presence of pain or other OA risk factors. Such structural changes in absence of knee symptoms should probably be considered as risk factors for early OA rather than disease.
AIM: To study the development of early knee osteoarthritis (OA) in subjects with and without risk factors for knee OA. METHODS: We studied 340 subjects from the Osteoarthritis Initiative (OAI), aged 45-55 years (51% women), free of radiographic knee OA at baseline (n = 294 with and n = 46 without knee pain and other OA risk factors). At baseline, 24, 48, 72 and 96 months we compared the two groups for prevalence and overlap of knee OA as defined by magnetic resonance imaging (MRI-based OA), x-rays (Kellgren-Lawrence grade [KLG] ≥ 1), and pain, using a logistic mixed model. We studied the group differences (%) over time by subtracting the OA prevalence of those without risk factors from the group with risk factors. RESULTS: The group with OA risk factors had higher proportions of MRI-based OA than the group without OA risk factors at all visits, but the difference diminished at 72 months (72 months difference = 11.9%, 95% confidence intervals [CI] = -2.3-26.1). Further, at 72 months, the presence of KLG ≥ 1 were similar in the two groups (-3.5%, 95% CI = -15.2-8.2). The proportion fulfilling all three OA definitions was 1.7% at 24 months and 4.8% at 72 months of those with OA risk factors and 0% and 2.2%, respectively, in those without. CONCLUSION: Structural changes of the knee are common irrespective of the presence of pain or other OA risk factors. Such structural changes in absence of knee symptoms should probably be considered as risk factors for early OA rather than disease.
Authors: Martin Brom; Ignacio J Gandino; Johana B Zacariaz Hereter; Marina Scolnik; Florencia B Mollerach; Leandro G Ferreyra Garrott; Josefina Marin; Santiago O Ruta; Javier E Rosa; Ricardo D García-Mónaco; Enrique R Soriano Journal: Front Med (Lausanne) Date: 2020-07-03
Authors: Eleonor Svantesson; Eric Hamrin Senorski; Kate E Webster; Jón Karlsson; Theresa Diermeier; Benjamin B Rothrauff; Sean J Meredith; Thomas Rauer; James J Irrgang; Kurt P Spindler; C Benjamin Ma; Volker Musahl Journal: Knee Surg Sports Traumatol Arthrosc Date: 2020-08-06 Impact factor: 4.342